Please note that birth and death certificates were not required in South Carolina until 1915, marriage certificates starting in 1911.  Therefore, other sources, such as newspapers, church records, cemetery inscriptions, may be the only alternative for earlier information; a few areas did keep some earlier records on their own.

All Saints' Church, Waccamaw, 1739-1968
SCR 283 Bul

St. Stephen's Episcopal Church, St. Stephen, SC
SCR 283 Misenhel

Register of St. Philip's Church (3 vols. 1720-1822)
SCR 283 Reg

Church register of St. John's Lutheran Church (3 vols.)
SCR 284.1757 St.

Parish Registers of Prince George Winyah Church, Georgetown, South Carolina, 1815-1936
SCR 929.375789 Holcomb

Birth Records of Charleston County Health Department, 1877-1927 (with gaps).  Not indexed.
SCR Microfilm

St. Matthew's German Evangelical Lutheran Church of Charleston
SCR Microfilm

South Carolina Lowcountry Church Records (Over 1800 microfiche containing records of many Lowcounty churches from the 1700's to the 1900's. A list of churches included is available).
SCR microfiche