Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study.

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  • Additional Information
    • Abstract:
      BACKGROUND: Oxidative stress may play an important role in the etiology of primary open-angle glaucoma (POAG). The association between risk of POAG and lead exposure, which is an environmental source of oxidative stress, has not been fully investigated yet. OBJECTIVE: Our objective was to determine the association between bone lead--a biomarker of cumulative lead dose (tibia lead) or an endogenous source of stored lead (patella lead)--and incident POAG. METHODS: We examined a prospective cohort of 634 POAG-free men [mean baseline age=66:8 y of age (SD=6:7)] from the Normative Aging Study (NAS) who had tibia and patella K X-ray fluorescence lead measurements between 1 January 1991 and 31 December 1999. They also had standard ocular evaluations by NAS optometrists until 31 December 2014. POAG cases were identified by consistent reports of enlarged or asymmetric cup-to-disc ratio together with visual field defect or existence of disc hemorrhage. We used Cox proportional hazards regressions to estimate hazard ratios (HRs) of incident POAG and adjusted survival curves to examine changes in the risk of POAG during follow-up according to bone lead quartiles. RESULTS: We identified 44 incident cases of POAG by the end of follow-up (incidence rate=74 per 10,000 person-years; median follow-up=10:6 y). In fully adjusted models, 10-fold increases in patella lead and tibia lead were associated with HRs of 5.06 (95% CI: 1.61, 15.88, p=0:005) and 3.07 (95% CI: 0.94, 10.0, p=0:06), respectively. The HRs comparing participants in the third and fourth quartiles with the lowest quartile were 3.41 (95% CI: 1.34, 8.66) and 3.24 (95% CI: 1.22, 8.62) for patella lead (p-for-trend=0:01), and 3.84 (95% CI: 1.54, 9.55) and 2.61 (95% CI: 0.95, 7.21) for tibia lead (p-for-trend=0:02). CONCLUSIONS: Our study provides longitudinal evidence that bone lead may be an important risk factor for POAG in the U.S. population. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
      2Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, Michigan, USA
      3Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
      4Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
      5Real World Evidence, Evidera, Pharmaceutical Product Development, LLC (PPD), Boston, Massachusetts, USA
      6Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center at University of Utah School of Medicine, Salt Lake City, Utah, USA
      7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
      8Veterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
      9Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
      10Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
      11Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    • ISSN:
      0091-6765
    • Accession Number:
      10.1289/EHP3442
    • Accession Number:
      131644683
  • Citations
    • ABNT:
      WEIYE WANG et al. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives, [s. l.], v. 126, n. 8, p. 1–9, 2018. Disponível em: . Acesso em: 21 nov. 2019.
    • AMA:
      Weiye Wang, Sayoko Moroi, Bakulski K, et al. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives. 2018;126(8):1-9. doi:10.1289/EHP3442.
    • APA:
      Weiye Wang, Sayoko Moroi, Bakulski, K., Mukherjee, B., Weisskopf, M. G., Schaumberg, D., … Sung Kyun Park. (2018). Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives, 126(8), 1–9. https://doi.org/10.1289/EHP3442
    • Chicago/Turabian: Author-Date:
      Weiye Wang, Sayoko Moroi, Kelly Bakulski, Bhramar Mukherjee, Marc G. Weisskopf, Debra Schaumberg, David Sparrow, Pantel S. Vokonas, Howard Hu, and Sung Kyun Park. 2018. “Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study.” Environmental Health Perspectives 126 (8): 1–9. doi:10.1289/EHP3442.
    • Harvard:
      Weiye Wang et al. (2018) ‘Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study’, Environmental Health Perspectives, 126(8), pp. 1–9. doi: 10.1289/EHP3442.
    • Harvard: Australian:
      Weiye Wang, Sayoko Moroi, Bakulski, K, Mukherjee, B, Weisskopf, MG, Schaumberg, D, Sparrow, D, Vokonas, PS, Hu, H & Sung Kyun Park 2018, ‘Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study’, Environmental Health Perspectives, vol. 126, no. 8, pp. 1–9, viewed 21 November 2019, .
    • MLA:
      Weiye Wang, et al. “Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study.” Environmental Health Perspectives, vol. 126, no. 8, Aug. 2018, pp. 1–9. EBSCOhost, doi:10.1289/EHP3442.
    • Chicago/Turabian: Humanities:
      Weiye Wang, Sayoko Moroi, Kelly Bakulski, Bhramar Mukherjee, Marc G. Weisskopf, Debra Schaumberg, David Sparrow, Pantel S. Vokonas, Howard Hu, and Sung Kyun Park. “Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study.” Environmental Health Perspectives 126, no. 8 (August 2018): 1–9. doi:10.1289/EHP3442.
    • Vancouver/ICMJE:
      Weiye Wang, Sayoko Moroi, Bakulski K, Mukherjee B, Weisskopf MG, Schaumberg D, et al. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives [Internet]. 2018 Aug [cited 2019 Nov 21];126(8):1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=131644683