Putting the Brakes on Huntington Disease in a Mouse Experimental Model.

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    • Abstract:
      The article examines the genetic aspects of Huntington disease(HD) using a mouse experimental model. Topics discussed include the distinction between the molecular mechanisms of intergenerational and somatic expressions, the repair of DNA oxidative damage, and the role of somatic expansions in disease pathophysiology. Also noted is the use of a mitochondrial scavenger of ROS called XJB-5-131 to treat HD mice.