Renal tubular acidosis type IV as a complication of lupus nephritis.

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  • Additional Information
    • Author-Supplied Keywords:
      hyperkalemia
      Lupus nephritis
      renal tubular acidosis
    • Abstract:
      Renal tubular acidosis (RTA) is a rare complication of renal involvement of systemic lupus erythematosus (SLE). We describe a 24-year-old male with type IV lupus nephropathy as a presenting manifestation of SLE. He presented with improvement of renal function following induction therapy with three pulses of methylprednisolone and 500 mg biweekly pulses of cyclophosphamide. However, a week after the first pulse of cyclophosphamide, the patient presented with a significant increase in legs edema and severe hyperkalemia. Type IV RTA associated with hyporeninemic hypoaldosteronism was suspected in the presence of metabolic acidosis with a normal anion gap, severe hyperkalemia without worsening renal function, and urinary pH of 5. RTA was confirmed with a transtubular potassium concentration gradient of 2 and low levels of plasma aldosterone, renin, angiotensin II, and cortisol. Intravenous bicarbonate, high-dose furosemide, and fludrocortisone were administered with normalization of potassium levels and renal function. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Catalonia, Spain
      2Department of Nephrology and Renal Transplantation, Hospital Clínic, Barcelona, Catalonia, Spain
    • Full Text Word Count:
      1630
    • ISSN:
      0961-2033
    • Accession Number:
      10.1177/0961203315603143
    • Accession Number:
      113263914
  • Citations
    • ABNT:
      SÁNCHEZ-MARCOS, C. et al. Renal tubular acidosis type IV as a complication of lupus nephritis. Lupus, [s. l.], v. 25, n. 3, p. 307–309, 2016. DOI 10.1177/0961203315603143. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=aph&AN=113263914. Acesso em: 7 dez. 2019.
    • AMA:
      Sánchez-Marcos C, Hoffman V, Prieto-González S, Hernández-Rodríguez J, Espinosa G. Renal tubular acidosis type IV as a complication of lupus nephritis. Lupus. 2016;25(3):307-309. doi:10.1177/0961203315603143.
    • APA:
      Sánchez-Marcos, C., Hoffman, V., Prieto-González, S., Hernández-Rodríguez, J., & Espinosa, G. (2016). Renal tubular acidosis type IV as a complication of lupus nephritis. Lupus, 25(3), 307–309. https://doi.org/10.1177/0961203315603143
    • Chicago/Turabian: Author-Date:
      Sánchez-Marcos, C., V. Hoffman, S. Prieto-González, J. Hernández-Rodríguez, and G. Espinosa. 2016. “Renal Tubular Acidosis Type IV as a Complication of Lupus Nephritis.” Lupus 25 (3): 307–9. doi:10.1177/0961203315603143.
    • Harvard:
      Sánchez-Marcos, C. et al. (2016) ‘Renal tubular acidosis type IV as a complication of lupus nephritis’, Lupus, 25(3), pp. 307–309. doi: 10.1177/0961203315603143.
    • Harvard: Australian:
      Sánchez-Marcos, C, Hoffman, V, Prieto-González, S, Hernández-Rodríguez, J & Espinosa, G 2016, ‘Renal tubular acidosis type IV as a complication of lupus nephritis’, Lupus, vol. 25, no. 3, pp. 307–309, viewed 7 December 2019, .
    • MLA:
      Sánchez-Marcos, C., et al. “Renal Tubular Acidosis Type IV as a Complication of Lupus Nephritis.” Lupus, vol. 25, no. 3, Mar. 2016, pp. 307–309. EBSCOhost, doi:10.1177/0961203315603143.
    • Chicago/Turabian: Humanities:
      Sánchez-Marcos, C., V. Hoffman, S. Prieto-González, J. Hernández-Rodríguez, and G. Espinosa. “Renal Tubular Acidosis Type IV as a Complication of Lupus Nephritis.” Lupus 25, no. 3 (March 2016): 307–9. doi:10.1177/0961203315603143.
    • Vancouver/ICMJE:
      Sánchez-Marcos C, Hoffman V, Prieto-González S, Hernández-Rodríguez J, Espinosa G. Renal tubular acidosis type IV as a complication of lupus nephritis. Lupus [Internet]. 2016 Mar [cited 2019 Dec 7];25(3):307–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=aph&AN=113263914