Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      Animal cells
      Biochemistry
      Biology and life sciences
      Biomarkers
      Blood cells
      Blood pressure
      Cardiovascular diseases
      Cardiovascular medicine
      Cell biology
      Cellular types
      Cholesterol
      Chromosome biology
      Chromosome structure and function
      Chromosomes
      Education
      Glomerular filtration rate
      Immune cells
      Immunology
      Lipids
      Medicine and health sciences
      Physiology
      Renal physiology
      Research Article
      Schools
      Social sciences
      Sociology
      Telomere length
      Telomeres
      Vascular medicine
      White blood cells
    • Abstract:
      Background: Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations between LTL and cardiovascular disease. This may be due in part to the relationship of LTL with other biomarkers associated with cardiovascular disease risk. However, the strength of associations between LTL and adiposity, metabolic, proinflammatory, and cardiovascular biomarkers has not been systematically evaluated in a United States nationally representative population.Methods and Findings: We examined associations between LTL and 17 cardiovascular biomarkers, including lipoproteins, blood sugar, circulatory pressure, proinflammatory markers, kidney function, and adiposity measures, in adults ages 20 to 84 from the cross-sectional US nationally representative 1999-2002 National Health and Nutrition Examination Survey (NHANES) (n = 7,252), statistically adjusting for immune cell type distributions. We also examine whether these associations differed systematically by age, race/ethnicity, gender, education, and income. We found that a one unit difference in the following biomarkers were associated with kilobase pair differences in LTL: BMI -0.00478 (95% CI -0.00749--0.00206), waist circumference -0.00211 (95% CI -0.00325--0.000969), percentage of body fat -0.00516 (95% CI -0.00761--0.0027), high density lipoprotein (HDL) cholesterol 0.00179 (95% CI 0.000571-0.00301), triglycerides -0.000285 (95% CI -0.000555--0.0000158), pulse rate -0.00194 (95% CI -0.00317--0.000705), C-reactive protein -0.0363 (95% CI 0.0601--0.0124), cystatin C -0.0391 (95% CI -0.0772--0.00107). When using clinical cut-points we additionally found associations between LTL and insulin resistance -0.0412 (95% CI -0.0685--0.0139), systolic blood pressure 0.0455 (95% CI 0.00137-0.0897), and diastolic blood pressure -0.0674 (95% CI -0.126--0.00889). These associations were 10%-15% greater without controlling for leukocyte cell types. There were very few differences in the associations by age, race/ethnicity, gender, education, or income. Our findings are relevant to the relationships between these cardiovascular biomarkers in the general population but not to cardiovascular disease as a clinical outcome.Conclusions: LTL is most strongly associated with adiposity, but is also associated with biomarkers across several physiological systems. LTL may thus be a predictor of cardiovascular disease through its association with multiple risk factors that are physiologically correlated with risk for development of cardiovascular disease. Our results are consistent with LTL being a biomarker of cardiovascular aging through established physiological mechanisms. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of PLoS Medicine is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Medicine, Stanford University, Stanford, California, United States of America
      2Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America
      3Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
      4Department of Environmental and Occupational Health, George Washington University, Washington, DC, United States of America
      5Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America
      6Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    • ISSN:
      1549-1277
    • Accession Number:
      10.1371/journal.pmed.1002188
    • Accession Number:
      119832201
  • Citations
    • ABNT:
      REHKOPF, D. H. et al. Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults. PLoS Medicine, [s. l.], v. 13, n. 11, p. 1–24, 2016. DOI 10.1371/journal.pmed.1002188. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=aph&AN=119832201. Acesso em: 4 jul. 2020.
    • AMA:
      Rehkopf DH, Needham BL, Lin J, et al. Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults. PLoS Medicine. 2016;13(11):1-24. doi:10.1371/journal.pmed.1002188.
    • AMA11:
      Rehkopf DH, Needham BL, Lin J, et al. Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults. PLoS Medicine. 2016;13(11):1-24. doi:10.1371/journal.pmed.1002188
    • APA:
      Rehkopf, D. H., Needham, B. L., Lin, J., Blackburn, E. H., Zota, A. R., Wojcicki, J. M., & Epel, E. S. (2016). Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults. PLoS Medicine, 13(11), 1–24. https://doi.org/10.1371/journal.pmed.1002188
    • Chicago/Turabian: Author-Date:
      Rehkopf, David H., Belinda L. Needham, Jue Lin, Elizabeth H. Blackburn, Ami R. Zota, Janet M. Wojcicki, and Elissa S. Epel. 2016. “Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.” PLoS Medicine 13 (11): 1–24. doi:10.1371/journal.pmed.1002188.
    • Harvard:
      Rehkopf, D. H. et al. (2016) ‘Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults’, PLoS Medicine, 13(11), pp. 1–24. doi: 10.1371/journal.pmed.1002188.
    • Harvard: Australian:
      Rehkopf, DH, Needham, BL, Lin, J, Blackburn, EH, Zota, AR, Wojcicki, JM & Epel, ES 2016, ‘Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults’, PLoS Medicine, vol. 13, no. 11, pp. 1–24, viewed 4 July 2020, .
    • MLA:
      Rehkopf, David H., et al. “Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.” PLoS Medicine, vol. 13, no. 11, Nov. 2016, pp. 1–24. EBSCOhost, doi:10.1371/journal.pmed.1002188.
    • Chicago/Turabian: Humanities:
      Rehkopf, David H., Belinda L. Needham, Jue Lin, Elizabeth H. Blackburn, Ami R. Zota, Janet M. Wojcicki, and Elissa S. Epel. “Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.” PLoS Medicine 13, no. 11 (November 29, 2016): 1–24. doi:10.1371/journal.pmed.1002188.
    • Vancouver/ICMJE:
      Rehkopf DH, Needham BL, Lin J, Blackburn EH, Zota AR, Wojcicki JM, et al. Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults. PLoS Medicine [Internet]. 2016 Nov 29 [cited 2020 Jul 4];13(11):1–24. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=aph&AN=119832201