胰岛素样生长因子1 对2 型糖尿病合并骨质疏松中骨钙素表达的影响.

Effect of insulin-like growth factor 1 on osteocalcin expression in type 2 diabetic patients with osteoporosis.

Epidemiological study shows that the risk of fracture occurrence in patients with type 2 diabetes is higher than that in the healthy population． Therefore，enough attention to osteoporosis and fracture complication should be paid by patients with type 2 diabetes． Studies at the molecular mechanism level shows that the occurrence of type 2 diabetes with osteoporosis may be associated with changes of insulin-like growth factor 1，glucose toxicity，sclerostin，osteocalcin，oxidative stress，and other metabolic pathways． Insulin-like growth factor 1 is a regulator of bone formation． It plays an important role in the regulation of bone remodeling process mediated by osteoblasts and osteoclasts． Osteocalcin is a non-collagen protein produced by osteoblasts． It reflects the activity of osteoblasts，and it is often used as a specific marker of bone formation and bone turnover． Studies have shown that insulin-like growth factor 1 stimulates osteocalcin synthesis in a dose-dependent manner． This paper reviews the effect of insulin-like growth factor 1 on the expression of osteocalcin in type 2 diabetic patients with osteoporosis，the correlation between osteocalcin and insulin like growth factor 1 in type 2 diabetic patients，the early diagnosis and treatment of osteoporosis，prevention of fractures，and the quality of life of the patients． [ABSTRACT FROM AUTHOR]

随着流行病学的调查研究发现，2 型糖尿病患者与健康人群相比，其罹患骨折事件的发生率明显增高，所以骨质疏松及 骨折等并发症需引起2 型糖尿病患者的足够重视。在分子机制层面的研究显示，2 型糖尿病合并骨质疏松的发生可能与胰岛 素样生长因子1、葡萄糖毒性、硬骨素、骨钙素及氧化应激等多种代谢途径的改变有关。胰岛素样生长因子1 是骨形成的调节 因子，在调节成骨细胞和破骨细胞介导的骨骼重建过程中起着重要的作用。骨钙素是由成骨细胞产生的一种非胶原蛋白，能 够反映成骨细胞的活性，常作为骨形成和骨转换的特异性指标。有研究显示，胰岛素样生长因子1 以浓度依赖方式刺激骨钙 素的合成增加，本文试就胰岛素样生长因子1 对2 型糖尿病合并骨质疏松中骨钙素表达的影响做一综述，探讨在2 型糖尿病 合并骨质疏松患者中胰岛素样生长因子1 与骨钙素之间的相关性，以期对2 型糖尿病合并骨质疏松患者能够进行早期诊断及 治疗，预防骨折事件的发生，提高患者生活质量。 [ABSTRACT FROM AUTHOR]

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