探讨糖尿病患者的骨转换标志物的变化与骨质疏松的关系.

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    • Alternate Title:
      Investigation on the relationship between bone turnover markers and osteoporosis in diabetic patients.
    • Abstract:
      Objective To investigate the relationship between bone turnover and osteoporosis in diabetic patients with different blood glucose control levels, and to provide reference for controlling fracture risk. Methods  A total of 494 patients in the Department of Endocrinology of our hospital from January 2017 to September 2018 were enrolled in the study. Glycosylated hemoglobin A1c (HbA1c), 25-hydroxyvitamin D (25-VD), type I collagen amino-lengthening peptide (P1NP), β-crosslaps (β- Cross), and osteocalcin (OC) were measured. According to the level of glycosylated hemoglobin, the diabetic patients were divided into group A (HbA1c < 7. 0%), group B (7. 0%
    • Abstract:
      目的 探讨不同血糖控制水平糖尿病患者的骨转换情况与骨质疏松的关系,为控制患者骨折风险提供参考依据。方法 将2017 年1 月至2018 年9 月于北京大学国际医院内分泌科就诊的患者494 例纳入研究,分别测定糖化血红蛋白(glycosylated hemoglobin,HbA1c)与25 羟维生素D(25-hydroxyvitamin D,25-VD),I 型胶原氨基延长肽(type I collagen amino-lengthening peptide,P1NP),β 胶原降解产物(β-crosslaps,β-Cross),骨钙素(osteocalcin,OC)。按糖化血红蛋白水平将糖尿病患者分为A 组(HbA1c<7. 0%)、B 组(7. 0%≤HbA1c<9. 0%)、C 组(HbA1c≥9. 0%),同期非糖尿病体检人群45 例作为对照组。对不同分 组的测定结果进行统计分析。结果 糖化血红蛋白与25 羟维生素D、I 型胶原氨基延长肽、β 胶原降解产物、骨钙素均存在负 相关关系(P<0. 05),相关系数分别为-0. 11、-0. 10、-0. 10、-0. 19. 对照组4 项骨代谢标志物均高于A、B、C 3 个糖尿病患者组 (P<0. 05),糖尿病患者A 组的骨钙素水平高于B 组和C 组(P<0. 05)。结论 糖尿病患者血糖控制情况影响骨转换标志物 水平。骨钙素在骨转换标志物中是更为敏感的实验室检测指标,可能在糖尿病患者骨质疏松的诊断和治疗监测中更值得 关注。 [ABSTRACT FROM AUTHOR]
    • Abstract:
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