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Molecular characterization of bovine leukemia virus reveals existence of genotype 4 in Chinese dairy cattle.
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- Author(s): Yang, Yi1,2 (AUTHOR); Chen, Lina1 (AUTHOR); Dong, Maoli1 (AUTHOR); Huang, Wenjiang1,3 (AUTHOR); Hao, Xiaoli1 (AUTHOR); Peng, Yalan1 (AUTHOR); Gong, Zaicheng1 (AUTHOR); Qin, Aijian1,2 (AUTHOR); Shang, Shaobin1,2 (AUTHOR) ; Yang, Zhangping2,4 (AUTHOR)
- Source:
Virology Journal. 8/27/2019, Vol. 16 Issue 1, pN.PAG-N.PAG. 1p. 1 Color Photograph, 2 Diagrams, 2 Charts.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Bovine leukemia virus (BLV) causes enzootic bovine leucosis and is widely spread worldwide, except several European countries, Australia and New Zealand. Although BLV is highly prevalent in China, information about the genetic diversity and evolutionary dynamics of BLV among Chinese dairy herds is still lacking. To determine the genetic variability of BLV, 219 cows from four cities of Ningxia province of China were screened for BLV infection by fluorescence resonance energy transfer (FRET)-PCR and sequencing, 16 selected positive samples were subjected to molecular characterization. Phylogenetic analysis using the neighbor-joining (NJ) method on complete sequences of envelope (env) gene of BLV obtained from China and those available in GenBank (representing BLV genotypes 1–10) revealed that those Chinese strains belonged to genotypes 4 and 6. Totally, 23 mutations were identified and 16 of them were determined to be unique mutations among Chinese strains. Alignment of the deduced amino acid sequences demonstrated six mutations in glycoprotein 51 (gp51) and three mutations in glycoprotein 30 (gp30) located in the identified neutralizing domain (ND), CD8+ T cell epitope, E-epitope, B-epitope, gp51N12 and cytoplasmic domain of transmembrane protein. This study reported for the first time the BLV genotype 4 in China, and further studies are warranted to compare its immunogenicity and pathogenicity with other BLV genotypes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Virology Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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