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West Ashley Library
9 a.m. - 7 p.m.
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Folly Beach Library
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John L. Dart Library
9 a.m. - 7 p.m.
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St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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Wando Mount Pleasant Library
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An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders.
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- Author(s): Alghamdi, Mohammed1,2; Alasmari, Doaa1; Assiri, Amjad1; Mattar, Ehab1; Aljaddawi, Abdullah A.1; Alattas, Sana G.1; Redwan, Elrashdy M.1,3
- Source:
Journal of Immunology Research. 11/25/2019, p1-39. 39p. 1 Illustration, 9 Diagrams, 10 Charts.- Subject Terms:
- Source:
- Additional Information
- Abstract: A protein undergoes many types of posttranslation modification. Citrullination is one of these modifications, where an arginine amino acid is converted to a citrulline amino acid. This process depends on catalytic enzymes such as peptidylarginine deiminase enzymes (PADs). This modification leads to a charge shift, which affects the protein structure, protein-protein interactions, and hydrogen bond formation, and it may cause protein denaturation. The irreversible citrullination reaction is not limited to a specific protein, cell, or tissue. It can target a wide range of proteins in the cell membrane, cytoplasm, nucleus, and mitochondria. Citrullination is a normal reaction during cell death. Apoptosis is normally accompanied with a clearance process via scavenger cells. A defect in the clearance system either in terms of efficiency or capacity may occur due to massive cell death, which may result in the accumulation and leakage of PAD enzymes and the citrullinated peptide from the necrotized cell which could be recognized by the immune system, where the immunological tolerance will be avoided and the autoimmune disorders will be subsequently triggered. The induction of autoimmune responses, autoantibody production, and cytokines involved in the major autoimmune diseases will be discussed. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Immunology Research is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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