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Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.
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- Author(s): Gondalia, Rahul1 ; Holliday, Katelyn M.1,2; Baldassari, Antoine1; Justice, Anne E.1,3; Stewart, James D.1; Duanping Liao4; Yanosky, Jeff D.4; Engel, Stephanie M.1; Jordahl, Kristina M.5; Bhatti, Parveen5; Horvath, Steve6,7; Assimes, Themistocles L.8; Pankow, James S.9; Demerath, Ellen W.9; Guan, Weihua10; Fornage, Myriam11; Bressler, Jan12; North, Kari E.1,13; Conneely, Karen N.14; Yun Li15,16,17
- Source:
Environmental Health Perspectives. Jan2020, Vol. 128 Issue 1, p017004-1-017004-12. 12p. 4 Charts, 2 Graphs, 1 Map.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: BACKGROUND: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence of PM-associated leukocytosis is inconsistent and largely based on small, cross-sectional, and/or unrepresentative study populations. OBJECTIVES: Our objective was to estimate PM-leukocyte associations among U.S.women and men in the Women's Health Initiative and Atherosclerosis Risk in Communities study (푛 = 165,675). METHODS: We based the PM-leukocyte estimations on up to four study visits per participant, at which peripheral blood leukocytes and geocoded address-specific concentrations of PM ≤10, ≤2.5, and 2.5-10μm in diameter (PM10, PM2.5, and PM2.5-10, respectively) were available. We multiply imputed missing data using chained equations and estimated PM-leukocyte count associations over daily to yearly PM exposure averaging periods using center-specific, linear, mixed, longitudinal models weighted for attrition and adjusted for sociodemographic, behavioral, meteorological, and geographic covariates. In a subset of participants with available data (푛 = 8,457), we also estimated PM-leukocyte proportion associations in compositional data analyses. RESULTS: We found a 12 cells/μL (95% confidence interval: -9, 33) higher leukocyte count, a 1.2% (0.6%, 1.8%) higher granulocyte proportion, and a -1.1% (-1.9%, -0.3%) lower CD8+ T-cell proportion per 10-μg/m³ increase in 1-month mean PM2.5. However, shorter-duration PM10 exposures were inversely and only modestly associated with leukocyte count. DISCUSSION: The PM2.5-leukocyte estimates, albeit imprecise, suggest that among racially, ethnically, and environmentally diverse U.S. populations, sustained, ambient exposure to fine PM may induce subclinical, but epidemiologically important, inflammatory effects. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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