绝经后女性骨密度与骨代谢生化指标的相关性分析.

Correlation between bone mineral density and biochemical markers of bone metabolism in postmenopausal women.

Objective Analysis of the correlation between bone mineral density (BMD) and biochemical markers of bone metabolism in postmenopausal women. Methods 151 postmenopausal women were selected from January 2017 to December 2018 in our hospital. According to T-score of BMD, the patients were divided into three groups: osteoporosis group (83 cases), low bone mass group (47 cases) and normal bone mass group (21 cases). The differences in biochemical indexes of bone metabolism among the three groups were compared, and the correlation between BMD and biochemical indexes of bone metabolism was analyzed. Results Levels of parathyroid hormone (PTH), propeptide of type I procollagen (P1NP) and β-C-terminal telopeptide of type I collagen (β-CTX) in osteoporosis group were significantly higher than those in low bone mass group and normal bone mass group (P<0.05), and in low bone mass group was significantly higher than those in normal bone mass group (P<0.05). Level of 25(OH)D3 in osteoporosis group was significantly lower than that that in low bone mass group and normal bone mass group (P<0.05), and in low bone mass group significantly lower than that in normal bone mass group (P<0.05). There were no significant differences in levels of serum calcium, serum phosphorus, bone specific alkaline phosphatase (BALP) and bone gla protein (BGP) among the three groups (P>0.05). Spearman correlation analysis showed that there was a negative correlation between PTH, P1NP, β-CTX and bone mineral density (r= -0.538, 0.520, 0.462, P<0.05), and a positive correlation between 25(OH)D3 and BMD (r= 0.517, P<0.05). There was no significant correlation between serum calcium, serum phosphorus, BALP, BGP and bone mineral density (P>0.05). Conclusion There was a significant correlation between bone mineral density and serum 25(OH)D3, PTH, P1NP and β-CTX levels in postmenopausal women. The monitoring of biochemical markers of bone metabolism was helpful for the early diagnosis of osteoporosis in postmenopausal women. [ABSTRACT FROM AUTHOR]

目的 分析绝经后女性骨密度（bone mineral density, BMD）与骨代谢生化指标的相关性。方法 选取西南医科大学附属医院2017年1月至2018年12月收治的绝经后女性患者151例。根据骨密度T值将患者分为骨质疏松组（83例）、骨量低下组（47例）和骨量正常组（21例），比较三组患者骨代谢生化指标的差异，并对各项指标与BMD进行相关性分析。结果 骨质疏松组甲状旁腺素（PTH）、Ⅰ型前胶原氨基末端前肽（P1NP）、Ⅰ型胶原羧基端肽 β 特殊序列（β-CTX）显著高于骨量低下组和骨量正常组（P<0.05），骨量低下组显著高于骨量正常组（P<0.05）。骨质疏松组体质量指数（bone mass index, BMI）、25（OH）D3显著低于骨量低下组和骨量正常组（P<0.05），骨量低下组显著低于骨量正常组（P<0.05）。血钙、血磷、骨钙素（BGP）、血清的骨特异性碱性磷酸酶（BALP）在三组之间比较，差异无明显统计学意义（P>0.05）。Spearman相关分析显示，PTH、P1NP、β-CTX与骨密度呈负相关（r= -0.538，-0.520，-0.462，P<0.05），25（OH）D3与骨密度呈正相关（r= 0.517，P<0.05），血钙、血磷、BALP、BGP与骨密度无相关性（P>0.05）。结论 血清25（OH）D3、PTH、P1NP、β-CTX与骨密度存在显著相关性，骨代谢生化指标监测有助于绝经后女性骨质疏松的早期诊断。 [ABSTRACT FROM AUTHOR]

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