Wnt/β-catenin信号通路在骨肉瘤与骨重建及血管生成中的多重话题.

Wnt/beta-catenin signaling pathway: multiple roles in osteosarcoma, bone remodeling and angiogenesis.

BACKGROUND: The Wnt/β-catenin signaling pathway plays a key role in osteosarcoma tumorigenesis and bone remodeling, and its roles in angiogenesis and immune surveillance are the two key mechanisms of metastatic dissemination. OBJECTIVE: To review the role of Wnt/β-catenin pathway in the occurrence and development of osteosarcoma and its regulatory role in specific microenvironment. METHODS: PubMed database was searched for relevant articles on the relationship between Wnt/β-catenin pathway and bone tumors using the search terms of “Wnt/β-catenin; bone tumors.” The search time for publications was from 2000 to 2020. RESULTS AND CONCLUSION: The typical Wnt/β-catenin signaling pathway plays an important role in the growth and metastasis of osteosarcoma by directly acting on osteosarcoma cells and indirectly regulating cell activity in osteosarcoma. The Wnt/β-catenin pathway also participates in the hijacking of the bone tumor microenvironment by osteosarcoma cells, promotes the regulation of extracellular matrix, makes the tumor cells invasive, induces immune tolerance and angiogenesis in tumor cells, and eventually augments metastatic spread. In addition, the typical Wnt signaling pathway abnormally activated in osteosarcoma cells seems to be closely related to cell proliferation, induction of epithelial-mesenchymal transition-like processes, acquisition of osteosarcoma-promoting tumor cell stem cell characteristics, and metastatic spread. [ABSTRACT FROM AUTHOR]

背景：Wnt/β-catenin 信号通路在骨肉瘤的肿瘤发生和骨重建中起的关键作用，及其在血管生成和免疫监视 中的意义，是转移性播散的 2 个关键机制。 目的：文章就 Wnt/β-catenin 通路在骨肉瘤发生发展中的作用及其对特定微环境的调控进行综述。 方法：检索 2000 年至 2020 年为止的 PubMed 数据库，以 “Wnt/β-catenin；bone tumors” 为英文检索词， 得到 Wnt/β-catenin 通路与骨肿瘤关系的相关研究。 结果与结论：典型的 Wnt/β-catenin 信号通路通过直接作用于骨肉瘤细胞和间接调节骨肉瘤细胞活性 2 种方 式在骨肉瘤生长和转移过程中起着重要作用。Wnt/β-catenin 通路也参与了骨肉瘤细胞对骨肿瘤微环境的劫 持，促进细胞外基质的调节，使肿瘤细胞具有侵袭性，诱导肿瘤细胞的免疫耐受和血管生成，最终导致转 移扩散的增加。另外，骨肉瘤细胞中典型Wnt 信号通路的异常激活似乎与细胞增殖、上皮间质转化样过程 的诱导、骨肉瘤促肿瘤细胞干细胞特性的获得以及转移扩散密切相关。 [ABSTRACT FROM AUTHOR]

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