Lack of reproducibility in osteocalcin-deficient mice.

However, the bone volumes of both trabecular and cortical bone and bone formation in our Ocn SP -/- sp mice and Williams's Ocn SP -/- sp mice were normal [[2]]. Furthermore, the bone phenotypes reported in Karsenty's Ocn SP -/- sp mice were not reproduced in a recent paper that analyzed bone morphology and showed cortical thickness in the radius was normal [[4]]. Since we were unable to reproduce the bone phenotypes of Ocn SP -/- sp mice, we examined bone quality, glucose metabolism, testosterone synthesis in testis, and muscle mass. [Extracted from the article]

Copyright of PLoS Genetics is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)