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绝经后血清BMP-7、0CN水平与骨质疏松的相关性 研究.
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- Author(s): 佘丽金1; 温广宇1 ; 崔红旺2
- Source:
Chinese Journal of Osteoporosis. Sep2020, Vol. 26 Issue 9, p1306-1310. 5p. - Source:
- Additional Information
- Alternate Title: Study on the correlation between the levels of serum BMP-7 and OCN and osteoporosis in postmenopausal women.
- Abstract: Objective To investigate the correlation between the levels of serum bone morphogenetic protein-7 ( BMP-7), osteocalcin ( OCN ) in postmenopausal osteoporosis ( OP) patients and bone metabolism indexes of bone specific alkaline phosphatase (BAP), type I collagen cross-linked peptide ( NTX) and bone mineral density ( BMD). Methods Ninety-three postmenopausal women with OP treated in the hospital from May 2017 to March 2019 were selected as OP group, and 86 postmenopausal women who had health examination in the same period were selected as the control group. The general data of the two groups were compared. The serum levels of BMP-7 and OCN in the two groups were measured using real-time fluorescent quantitative PCR (qRT-PCR). The serum levels of BAP and NTX were detected using enzyme-linked immunosorbent assay (ELISA). The ratio of BAP/NTX was calculated. Bone mineral density was measured using dual energy X-ray absorptiometry. The relationship between the expression levels of BMP-7, OCN and bone metabolism related indexes, BMD, and the relationship between the expression levels of BMP-7 and OCN in OP patients were analyzed. Logistic regression was used to analyze the influencing factors of OP. Results The serum levels of estradiol, BMP-7, OCN, and BAP/NTX, and BMD in the OP group were significantly lower than those in the control group (11. 962,9. 969,12. 823, 4. 052, 18. 215, respectively, all P < 0. 05). The serum levels of BAP and NTX in the OP group were significantly higher than those in control group (f= 4.014,9.092, respectively, both P < 0. 05). The expressions of BMP-7 and OCN were negatively correlated with BAP and NTX in OP patients (all P < 0. 05) , and positively coiTelated with BAP / NTX and BMD (P < 0.05). The expression of BMP-7 was positively correlated with OCN (i° <0‘ 05). Estradiol,BMP-7,OCN,and BMD were the protective factors of OP (95% C7=0. 536-0. 978,0. 374-0. 825, 0. 438-0. 913, 0. 335-0. 916, respectively, P< 0. 05). BAP and NTX were the risk factors of OP (95% CI= 1. 336-1.859, 1.427-2.357, respectively, P< 0.05). Conclusion The expressions of BMP-7 and OCN in postmenopausal women are down-regulated. BMP-7 and OCN are closely related to bone metabolism index and BMD, and they may interact with BAP, NTX, and BMD, and play a role in the development of OP. [ABSTRACT FROM AUTHOR]
- Abstract: 目的探究骨形态发生蛋白-7(BMP-7)、骨钙素(0CN)在绝经后骨质疏松(0P)患者血清中的水平与骨代谢指标骨特 异性碱性磷酸酶(BAP)、1型胶原交联氨基末端肽(NTX)及骨密度(BMD)的相关性。方法选取2017年5月至2019年3月 收治的93例绝经女性0P患者作为0P组;并以同期来我院进行健康体检的86例绝经女性作为对照组进行研究;以实时荧光 定量PCR(qRT-PCK)法检测两组受试者血清J3MJP-7、OCW表达水平;以酶联免疫吸附法(ELLSA)检测两组受试者血清BAJP、 NTX水平,计算BAP/NTX比值;利用双能X线骨密度仪测定两组受试者骨密度;分析0P患者血清BMP-7、0CN表达水平与 骨代谢相关指标、BMD的相关性及BMP-7表达水平与0CN的关系;Logistic冋归分析0P发生的影响因素。结果0P组患者 雌二醇水平、血清 BMP-7、0CN、BAP/NTX、BMD 水平均明显低于对照组 0 = 11. 962、9. 969、12. 823、4. 052、18. 215,尸均 < 0• 05) ;0JP组患者血清BAJP、NTX水平均明显高于对照组(( = 4. 014、9. 092,P均<0• 05) ;0P患者血清BMP-7、0CN表达水平与 BAP、NT)(均呈负相关(P i^<0. 05),与BAP/NTX、BMD均呈正相关(P均<0.05),BMP-7表达水平与0CN呈正相关(P<0.05);雌二醇、:6^0)是影响0?发生的保护险因素(95%67=0.536〜0.978、0.335〜0.916,尸均<0.05),:6人?、1'0^是影响0? 发生的危险因素(95%C7= 1.336〜1. 859J.427〜2. 357,尸均<0.05)。结论绝经女性血清BMP-7、0CN衷达水平下调,BMP-7、〇CN与骨代谢指标及JBMJD密切相关,两者可能与BAP、JNTX、BMi)相互影响,从而在0P发展进程中发挥作用 [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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