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West Ashley Library
9 a.m. – 7 p.m.
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Elevated Natural Killer Cell-Mediated Cytotoxicity Is Associated with Cavity Formation in Pulmonary Tuberculosis Patients.
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- Author(s): Li, Shanshan1 (AUTHOR); Wang, Dongpo2 (AUTHOR); Wei, Panjian3 (AUTHOR); Liu, Rongmei4 (AUTHOR); Guo, Jidong4 (AUTHOR); Yang, Bin3 (AUTHOR); Zhang, Hongtao3 (AUTHOR); Lu, Jie5 (AUTHOR); Gao, Mengqiu4 (AUTHOR); Pang, Yu1 (AUTHOR)
- Source:
Journal of Immunology Research. 10/4/2021, p1-8. 8p. 1 Diagram, 2 Charts, 2 Graphs.- Subject Terms:
- Source:
- Additional Information
- Abstract: Cavitation is a major pathological feature of pulmonary tuberculosis (TB). The study is aimed at investigating the mechanism of natural killer (NK) cells participating the cavity formation during Mycobacterium tuberculosis (MTB) infection. Human peripheral blood samples were donated by pulmonary TB patients with cavity or not. Real-time quantitative PCR and enzyme-linked immunosorbent assay were performed to analyze the expression of cytokines secreted by NK cells. And the cytotoxicity of NK cells was compared between two groups. Our data showed that NK cells were more abundant in cohorts of cavity. Increased abundance of granzyme A and granzyme B was observed in culture supernatants of NK cells isolated from cavitary TB patients, which also resulted in a higher level of nonviable MTB-infected monocytes. Our data firstly demonstrates that NK cells participate in cavity formation in pulmonary TB patients. The elevated level and increased cytotoxicity of NK cells accelerate the cavitary formulation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Immunology Research is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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