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Associations between the Maternal Exposome and Metabolome during Pregnancy.
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- Author(s): Minjian Chen1,2,3 ; Yusheng Guan1,2; Rui Huang1,2; Jiawei Duan1,2; Jingjing Zhou1,2; Ting Chen1,2; Xinru Wang1,2; Yankai Xia1,2 ; London, Stephanie J.3
- Source:
Environmental Health Perspectives. Mar2022, Vol. 130 Issue 3, p1-12. 12p. 4 Diagrams, 1 Chart, 3 Graphs.- Subject Terms:
*MAGNESIUM metabolism; *ORGANIC compound analysis; *HYPERTENSION; *STATISTICS; *POLLUTANTS; *HIGH performance liquid chromatography; *METABOLOMICS; *DURATION of pregnancy; *URINE; *METABOLISM in pregnancy; *GESTATIONAL age; *FETAL development; *PRENATAL exposure delayed effects; *MASS spectrometry; *BIRTH weight; *QUESTIONNAIRES; *DESCRIPTIVE statistics; *RESEARCH funding; *URINALYSIS; *LOGISTIC regression analysis; *DATA analysis; *DATA analysis software; *ENVIRONMENTAL exposure; *METABOLITES; *FAT; *CREATININE; *PREGNANCY - Source:
- Additional Information
- Abstract: BACKGROUND: Maternal exposure to environmental chemicals during pregnancy can influence various maternal and offspring health parameters. Modification of maternal metabolism by environmental exposure may be an important pathway for these impacts. However, there is limited evidence regarding exposure to a wide array of chemicals and the metabolome during pregnancy. OBJECTIVES: We investigated the relationship between the urinary exposome and metabolome during pregnancy. METHODS: Urine samples were collected in the first and third trimesters from 1,024 pregnant women recruited in prenatal clinics in Jiangsu Province, China. The exposome was analyzed using the first trimester sample with ultra-high performance liquid chromatography–high resolution accurate mass spectrometry (UHPLC-HRMS) and inductively coupled plasma mass spectrometry. The metabolome was analyzed using the third trimester sample with UHPLC-HRMS. We evaluated associations between each of 106 exposures in the first trimester with 139 metabolites in the third trimester. RESULTS: We identified 1,245 significant associations (푝<3.39 × 10-6, Bonferroni correction) between chemical exposures and maternal metabolism during pregnancy. Among elements, the largest number of the significant metabolic associations were observed for magnesium, and among organic compounds, for 4-tert-octylphenol. We used exposome–metabolome associations to explore mechanisms underlying published associations between prenatal chemical exposures and offspring health outcomes. This integration of the literature with our results suggests that reported associations between 10 analytes and birth weight, gestational age, fat deposition, neurobehavioral development, immunological disorders, and hypertension may be partially mediated by metabolites associated with these exposures. DISCUSSION: This high-dimensional analysis of the urinary exposome and metabolome identified many associations between chemical exposures and maternal metabolism during pregnancy. Integration of these associations with the literature on health outcomes of exposure suggests that environmental modulation of the maternal metabolome may play a role in the association between prenatal exposure on pregnancy and child health outcomes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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