The P53 Tumor Suppressor Gene: Understanding P53-Based Anticancer Therapies Utilizing Dietary Agents.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Author(s): Jurasunas, Serge
  • Source:
    Townsend Letter. Aug/Sep2015, Issue 385/386, p67-73. 7p.
  • Additional Information
    • Subject Terms:
      P53 antioncogene; TUMOR suppressor genes; APOPTOSIS; CELL death; CANCER research
    • Abstract:
      The P53 tumor suppressor gene, which has been dubbed both the "Guardian of the Genome" (Lane 1992) and Science "Molecule of the Year," is directly involved in the initiation of apoptosis and programmed cell death, to prevent an accumulation of abnormal cells. However, apoptosis evasion is a characteristic feature of human cancers that promote tumor formation and progression. Presently, P53 is known to play a key role in practically all types of human cancers, and the mutation or loss of P53 gene function can be identified in more than 50% of all human cancer cases worldwide. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Townsend Letter is the property of Townsend Letter Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)