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9 a.m. - 7 p.m.
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Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice.
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- Author(s): Tao, Jin; Nie, Yan; Hou, Yuanyuan; Ma, Xiaoyao; Ding, Guoyu; Gao, Jie; Jiang, Min; Bai, Gang
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 8/7/2016, Vol. 2016, p1-12. 12p. 3 Diagrams, 1 Chart, 3 Graphs. - Source:
- Additional Information
- Subject Terms: PROTEIN metabolism; LUNG injury prevention; ACUTE diseases; ALTERNATIVE medicine; ANIMAL experimentation; ANTI-inflammatory agents; BLOOD vessels; CELL adhesion molecules; CELLULAR signal transduction; FORECASTING; GLYCYRRHIZA; HERBAL medicine; IMMUNE system; CHINESE medicine; MICE; MUSCLE contraction; PROTEIN kinases; WORLD Wide Web; DNA-binding proteins; BIOINFORMATICS; PROTEOMICS; DESCRIPTIVE statistics; IN vivo studies; PHARMACODYNAMICS; PREVENTION
- Subject Terms:
- Abstract: Jie-Geng-Tang (JGT), a classic and famous traditional Chinese medicine (TCM) prescription composed of Platycodon grandiflorum (Jacq.) A. DC. (PG) and Glycyrrhiza uralensis Fisch. (GU), is well known for “clearing heat and relieving toxicity” and its ability to “diffuse the lung and relieve sore throat.” However, the mechanism underlying its action remains unclear. In this study, potential anti-inflammatory ingredients were screened and submitted to PharmMapper and the KEGG bioinformatics website to predict the target proteins and related pathways, respectively. Differentially expressed candidate proteins from acute lung injury (ALI) mice treated with JGT were identified by isobaric tags for relative and absolute quantitation (iTRAQ) and LC Triple-TOF. Eleven potential anti-inflammatory ingredients were found, including the derivatives of glycyrrhizic acid, licorice-saponin, liquiritin, and platycodigenin. A total of sixty-seven differentially expressed proteins were confirmed after JGT treatment with four therapeutic functions, including immunoregulation, anti-inflammation, ribosome, and muscle contraction. PG and GU comediate PI3K/Akt signal pathway inhibition of NF-κB, VCAM1, and ICAM1 release which primarily act on PI3K, PDK1, AKT, and GSK3β. GU markedly inhibits the ERK/MAPK signaling pathways and primarily acts on LCK, RAS, and MEK. A network was constructed using bioactive ingredients, targets, and pathways to determine the mechanism underlying JGT treatment of ALI. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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