Effect of Resveratrol Dry Suspension on Immune Function of Piglets.

CELL proliferation; ANIMAL experimentation; IMMUNITY; IMMUNIZATION; INTERFERONS; PICORNAVIRUS infections; SUPEROXIDE dismutase; SUSPENSIONS (Chemistry); SWINE; T cells; TUMOR necrosis factors; VIRAL antibodies; RESVERATROL; FLAVIVIRAL diseases

Resveratrol, a polyphenolic plant antitoxin, has a wide range of pharmacological activities. In this study, we systematically evaluated the effects of resveratrol dry suspension (RDS) on immune function in piglets that were treated with different doses of RDS for 2 weeks. The results showed that the RDS has significant effects on the development, maturation, proliferation, and transformation of T lymphocytes. RDS could regulate humoral immune responses by upregulating the release of IFN-γ and downregulating the release of TNF-α. After piglets were vaccinated against classical swine fever virus and foot-and-mouth disease virus, the antibody titers were significantly increased. RDS treatment showed an excellent resistance to enhance T-SOD activity. Values of blood routine and blood biochemistry showed no toxicity. These results suggested that RDS could be considered as an adjuvant to enhance immune responses to vaccines, as well as dietary additives for animals to enhance humoral and cellular immunity. [ABSTRACT FROM AUTHOR]

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