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Sensitive Biomarker Analysis of Xue-Fu-Zhu-Yu Capsule for Patients with Qi Stagnation and Blood Stasis Pattern: A Nested Case-Control Study.
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- Author(s): Chen, Guang (AUTHOR); He, Haoqiang (AUTHOR); Hu, Kun (AUTHOR); Gao, Jialiang (AUTHOR); Li, Jun (AUTHOR); Han, Mei (AUTHOR); Wang, Jie (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 11/18/2019, p1-13. 13p. 8 Diagrams, 2 Charts, 1 Graph. - Source:
- Additional Information
- Subject Terms: BIOMARKERS; PHARMACEUTICAL encapsulation; CELLULAR signal transduction; CONFIDENCE intervals; CORONARY disease; DIGESTIVE system diseases; HEMOSTASIS; HERBAL medicine; CHINESE medicine; MESSENGER RNA; POLYMERASE chain reaction; PROBABILITY theory; QUESTIONNAIRES; BIOINFORMATICS; CASE-control method; GENE expression profiling; MICRORNA; SEQUENCE analysis
- Abstract: Objectives. To identify the sensitive biomarker to predict the effectiveness of Xue-Fu-Zhu-Yu capsules (XFZYC). Methods. This nested case-control study included 5 patients with response to XFZYC in the treatment group, 5 patients with no response to XFZYC also in the treatment group, and 5 patients in the control group treated with placebo who participated in the previous RCT. The mRNAs, miRNAs, lncRNAs, and circRNAs were sequenced by next-generation sequencing and differential-expressed (DE) RNAs were identified if p value ≤ 0.05 and fold change ≥2, bioinformatics analysis was conducted in terms of function annotations and signaling pathways, and then sensitive biomarker was analyzed based on real-time PCR. Results. The distributions of clinical characteristics between the selected participants from treatment group and placebo group were well balanced. A total of 1156 DE RNAs, 388 miRNAs, 1954 lncRNAs, and 560 circRNAs were identified, which was associated the mechanism of XFZYC and composed the targeted potential biomarkers for further real-time PCR. The DE RNAs were enriched in KEGG pathways pertaining to pathogenesis of Qi Stagnation and Blood Stasis- (QS & BS-) & associated diseases such as coronary heart disease and digestive diseases. The expression level of FZD8 was significantly higher in response patients than that in nonresponse patients (p = 0.041) and circRNA_13799 significantly lower in response patients than that in nonresponse patients (p = 0.040) based on real-time PCR. Patients with higher expression level of FZD8 with 75% stratification have significantly higher reduction in the questionnaire score (p = 0.010), and the area under the curve (AUC) was 0.765 (95%CI = 0.593–0.936; p = 0.014). Conclusions. FZD8 might perform the sensitive biomarker for predicting the effectiveness of XFZYC. However, further prospective cohort study was warranted to confirm the exact specificity and sensitivity of this biomarker. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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