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Trichosanthes tricuspidata Lour. Methanol Extract Exhibits Anti-Inflammatory Activity by Targeting Syk, Src, and IRAK1 Kinase Activity.
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- Author(s): Ahuja, Akash (AUTHOR); Jeong, Deok (AUTHOR); Kim, Mi-Yeon (AUTHOR); Cho, Jae Youl (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 12/16/2019, p1-15. 15p. 1 Chart, 9 Graphs. - Source:
- Additional Information
- Subject Terms: ANIMAL experimentation; CELLULAR signal transduction; CYTOKINES; ETHANOL; GASTRITIS; HYDROCHLORIC acid; IMMUNOBLOTTING; INFLAMMATORY mediators; INTERLEUKINS; MACROPHAGES; MELONS; MESSENGER RNA; METHANOL; MICE; NITRIC oxide; POLYMERASE chain reaction; PROTEIN kinases; PROTEIN-tyrosine kinases; TRANSCRIPTION factors; TUMOR necrosis factors; DNA-binding proteins; NITRIC-oxide synthases; PLANT extracts; REVERSE transcriptase polymerase chain reaction; LIPOPOLYSACCHARIDES; IN vitro studies; IN vivo studies; PHARMACODYNAMICS
- Abstract: Trichosanthes tricuspidata Lour., also known as T. palmata Roxb, T. bracteata Lam., T. puber Blume, and Modecca bracteata, is a vine belonging to the Cucurbitaceae family (English name: redball snake gourd). Distributed in China, South and East Asia, and tropical Australia, it has been traditionally used as a medicinal plant for its antifever, laxative, anthelmintic properties and for migraine treatment. In this paper, we examined the effects of Trichosanthes tricuspidata Lour. ethanol extract (Tt-ME) in vitro and in vivo. To confirm the effects of Tt-ME on inflammatory responses, we conducted experimental analyses including level of nitric oxide (NO) production, RT-PCR, and immunoblotting and using a HCl/EtOH-induced gastritis animal model. Tt-ME attenuated the release of NO and decreased mRNA levels of inducible NO synthase (iNOS), TNF-α, and IL-6 in lipopolysaccharide- (LPS-) induced macrophages in a concentration-dependent manner. Tt-ME time-dependently suppressed nuclear translocation of nuclear factor kappa B (NF-κB) subunits p50 and p65, activator protein (AP-1) subunits c-Fos and c-Jun, and STAT3 transcriptional activity by inhibiting nuclear translocation of p50, p65, c-Fos, c-Jun, and STAT3. Tt-ME significantly downregulated NF-κB, MAPK, and JAK2 signaling by targeting Syk, Src, and IRAK1 protein kinases. Furthermore, matrix metalloproteinase-9 (MMP-9) expression and cell migration were observed to be downregulated by Tt-ME in LPS-activated macrophages. In vivo studies on Tt-ME also produced similar trends in Hcl/EtOH-induced gastritis mouse models by inhibiting proinflammatory cytokines and the inflammatory signaling pathway. Our results strongly suggest that Tt-ME exerted anti-inflammatory activity in LPS-stimulated macrophages and mouse models of acute inflammatory disease. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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