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Rhubarb-Aconite Decoction (RAD) Drug-Containing Serum Alleviated Endotoxin-Induced Oxidative Stress Injury and Inflammatory Response in Caco-2 Cells In Vitro.
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- Author(s): Du, Xiao-hong (AUTHOR); Chen, Qing-jun (AUTHOR); Song, Jian-bo (AUTHOR); Xie, Yan (AUTHOR); Zhi, Yan (AUTHOR); Sun, Ru-ru (AUTHOR); Liu, Guo-hui (AUTHOR); Kang, Xin (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 7/4/2020, p1-10. 10p. 1 Black and White Photograph, 4 Graphs. - Source:
- Additional Information
- Subject Terms: INTESTINAL injuries; ADENOSINE triphosphate; ANIMAL experimentation; CATALASE; CYTOSKELETAL proteins; ENDOTOXINS; EPITHELIAL cells; GENE expression; HERBAL medicine; INFLAMMATORY mediators; INTERLEUKIN-3; INTESTINAL diseases; LACTATE dehydrogenase; CHINESE medicine; MEMBRANE proteins; PEROXIDES; RATS; TUMOR necrosis factors; MALONDIALDEHYDE; OXIDATIVE stress; IN vitro studies; PHARMACODYNAMICS
- Abstract: Rhubarb-Aconite Decoction (RAD), a famous Chinese medicine prescription, has been widely used for treating intestinal injury. However, the effect of RAD on intestinal epithelial cells is unclear. The aim of this study was to investigate the effects of RAD drug-containing serum on the oxidative stress injury and inflammatory response induced by endotoxin (ET) in Caco-2 cells in vitro. Lipid peroxide malondialdehyde (MDA), lactate dehydrogenase (LDH), caspase-11, tumor necrosis factor-α(TNF-α), interleukin-3(IL-3), and cytokeratin (CK)18, adenosine triphosphate (ATP) activity, and intracellular free calcium ion levels were measured. The results showed that ET triggered the activation of caspase-11 and the massive release of TNF-α, increased the inhibitory rate of cell growth, MDA, and LDH expressions in Caco-2 cells. Moreover, RAD drug-containing serum could inhibit caspase-11 activation, decrease the release of TNF-α and IL-3, reduce intracellular free calcium ion, and enhance CK 18 expression and ATP activity. These novel findings demonstrated that ET-induced oxidative stress injury and inflammatory response of Caco-2 cells were improved by RAD drug-containing serum, indicating that RAD may be a good choice for the treatment of intestinal injury. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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