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Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta-Analysis.
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- Author(s): Yuan, Yi (AUTHOR); Xiong, Xing-jiang (AUTHOR); Li, Duo-duo (AUTHOR); Li, Hai-xia (AUTHOR); Fu, Jian-ping (AUTHOR); Wu, Hong-li (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 7/24/2020, p1-11. 11p. 2 Diagrams, 6 Charts, 2 Graphs. - Source:
- Additional Information
- Subject Terms: ARRHYTHMIA; ATRIAL arrhythmias; BRADYCARDIA; COMBINATION drug therapy; CONFIDENCE intervals; DIZZINESS; GASTROINTESTINAL diseases; HEART block; HERBAL medicine; CHINESE medicine; META-analysis; PROPAFENONE; TONGUE diseases; SYSTEMATIC reviews; PARESTHESIA; TREATMENT effectiveness; DISEASE incidence; XEROSTOMIA; ODDS ratio; DRUG administration; DRUG dosage
- Abstract: Objective. A meta-analysis was conducted on the clinical efficacy and safety of Wenxin granules and propafenone for the therapy of atrial premature beats (APBs). Methods. A randomized controlled trial (RCT) of Wenxin granules and propafenone in the therapy of APB was systematically searched until June 1, 2019. Meta-analysis was conducted with review manager (RevMan) 5.3. For the evaluation of methodological quality for randomized controlled trials, the Cochrane tool was used to assess the risk of bias. For the evaluation of the evidence quality, the online GRADEpro GDT was used. Results. Eleven RCTs with 1149 participants were included in this study. It has been identified that Wenxin granules combined with propafenone have better clinical efficacy than the use of propafenone alone in the treatment of APB (OR = 3.89, 95% CI (2.03, 7.44), P < 0.0001 , low-dose propafenone; OR = 4.24, 95% CI (1.32, 13.60), P = 0.02 , high-dose propafenone). There is no difference in clinical efficacy between the Wenxin granules alone and high-dose propafenone in the treatment of APB (OR = 1.17, 95% CI (0.65, 2.11), P = 0.60), and Wenxin granules alone are superior to the low-dose propafenone in the treatment of APB (OR = 2.56, 95% CI (1.34, 4.89), P = 0.004). Wenxin granules combined with propafenone can reduce the incidence of sinus bradycardia caused by propafenone (OR = 0.15, 95% CI (0.03, 0.70), P = 0.02). There was no significant difference between Wenxin granules combined with propafenone and propafenone alone in causing the atrioventricular block, dizziness, xerostomia, gastrointestinal symptoms, and tongue paresthesia. There was no significant difference between Wenxin granules alone and propafenone alone in causing dizziness, xerostomia, gastrointestinal symptoms, tongue paresthesia, frequent premature ventricular contractions, and prolongation of R-R interval. Conclusion. Very low-quality evidence showed that Wenxin granules may be superior to low-dose propafenone in the treatment of APB. Wenxin granules may reduce the incidence of sinus bradycardia caused by propafenone. Limited by the quality of included RCTs, the conclusions of this study still need further verification. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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