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Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis.
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- Author(s): Huang, Zifeng (AUTHOR); Si, Wenwen (AUTHOR); Li, Xinrong (AUTHOR); Ye, Shanyu (AUTHOR); Liu, Xuelei (AUTHOR); Ji, Yichun (AUTHOR); Hao, Xiaoqian (AUTHOR); Chen, Dongfeng (AUTHOR); Zhu, Meiling (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 4/16/2021, p1-11. 11p. 4 Color Photographs, 1 Black and White Photograph, 2 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson's disease (PD). However, how to control the level of ferroptosis in PD remains unclear. Clinically, moxibustion has been used to treat PD and has an apparent therapeutic effect on improving the motor symptoms of PD. In the present study, the PD rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, moxibustion was used to treat the PD rats. The expression of glutathione peroxidase 4 (GPX4) and Ferritin Heavy Chain 1 (FTH1), the level of reactive oxygen species (ROS), and the morphology of mitochondrial were detected to evaluate the level of ferroptosis. The results showed that moxibustion treatment of Shi's moxa sticks could reduce the behavioral score, alleviate the level of ferroptosis, decrease mitochondrial damage, and improve dopaminergic neuron survival. In conclusion, the present study results indicated that Shi's moxa sticks could effectively suppress the level of ferroptosis, thereby improving the survival of dopaminergic neurons in the SNpc of PD rats, which may provide a promising complementary and alternative therapy for PD patients. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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