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The Effect of Garlic Tablets on the Endometriosis-Related Pains: A Randomized Placebo-Controlled Clinical Trial.
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- Author(s): Amirsalari, Sudabeh (AUTHOR); Behboodi Moghadam, Zahra (AUTHOR); Taghizadeh, Ziba (AUTHOR); Jafar Abadi, Mina Naghi (AUTHOR); Sabaghzadeh Irani, Parichehr (AUTHOR); Goodarzi, Saied (AUTHOR); Ranjbar, Hadi (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 7/20/2021, p1-8. 8p. 1 Diagram, 2 Charts. - Source:
- Additional Information
- Subject Terms: THERAPEUTIC use of garlic; ENDOMETRIOSIS; CHRONIC pain; PAIN measurement; ANALYSIS of variance; RANDOMIZED controlled trials; T-test (Statistics); CHI-squared test; REPEATED measures design; ANALYSIS of covariance; DESCRIPTIVE statistics; PLANT extracts; STATISTICAL sampling; DATA analysis software; PAIN management; SYMPTOMS
- Abstract: Endometriosis is a common chronic inflammatory disease. Garlic contains components that have antiproliferative, anti-inflammatory, and antioxidative effects. The current study aimed to evaluate the effectiveness of garlic on endometriosis symptoms. This was a randomized placebo-controlled triple-blind clinical trial. A convenience sample of 60 women was randomly allocated into two groups. The intervention group received usual care supplemented with 400 mg garlic tablets, and the placebo group received identical placebo tablets. A four-part Visual Analogue Scale (VAS) was used to measure the severity of pains. The pains were measured on four occasions (before the intervention and on one-, two-, and three-month follow-ups). Data were analyzed using the t-test, chi-square, repeated measures ANOVA, and ANCOVA by SPSS 16. The overall severity of pain reduced from 6.51 ± 0.86 to 1.83 ± 1.25 in the intervention group (p < 0.05). It increased from 6.41 ± 1.12 to 6.65 ± 1.37 in the control group (p = 0.02). The repeated measures ANOVA showed that there is a significant difference in the change of pain scores between intervention and control groups (p < 0.001, np2 = 0.572). Garlic extract can reduce pelvic and back pain, dysmenorrhea, and dyspareunia which are important symptoms of endometriosis. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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