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Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice.
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- Author(s): Hu, Jin-Ryul (AUTHOR); Jung, Chul-Jong (AUTHOR); Ku, Seong-Min (AUTHOR); Jung, Dae-Hwa (AUTHOR); Bashir, Khawaja Muhammad Imran (AUTHOR); Ku, Sae-Kwang (AUTHOR); Choi, Jae-Suk (AUTHOR)
- Source:
Pharmaceutical Biology. Dec2021, Vol. 59 Issue 1, p319-332. 14p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Kyeongok-go (KOG) is a traditional mixed herb preparation consisting of Panax ginseng CA Meyer (Araliaceae), Poria cocos Wolf (Polyporaceae), Rehmannia glutinosa (Gaertner) Liboschitz ex Steudel (Orobanchaceae), and honey. Various pharmacological effects of KOG are reported, but the efficacy on respiratory diseases has not been evaluated. The anti-inflammatory, expectorant, and antitussive properties of KOG were examined using animal models of respiratory diseases. KOG (100, 200, and 400 mg/kg) was orally administered to ICR mice (n = 8) once a day for 11 days. Anti-inflammatory effects of vehicle, xylene, KOG and DEXA (1 mg/kg) were determined by monitoring edoema and redness of treated ears, and measuring the relative and absolute weight of each ear. Expectorant properties of vehicle, KOG and AM (250 mg/kg) were evaluated by observing body surface redness, and the amount of mucous secreted by the trachea. The antitussive potential of vehicle, NH4OH, KOG and TB (50 mg/kg) was evaluated by monitoring changes in the number of coughs (for 6 min). KOG (400 mg/kg) treated mice showed 31.29% and 30.72% (p < 0.01) decreases in the relative and absolute weights of each ear relative to xylene control mice, 39.06% increases (p < 0.01) in TLF OD values relative to intact vehicle control mice, and 59.53% decrease (p < 0.01) in coughing compared to NH4OH control mice. Dose-dependent changes were observed in all experimental models. KOG may be a potential therapeutic agent for the treatment of various respiratory diseases, particularly those caused by environmental toxins. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Pharmaceutical Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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