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9 a.m. – 7 p.m.
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Main Library
9 a.m. - 8 p.m.
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Folly Beach Library
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John L. Dart Library
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Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis.
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- Author(s): Islam, Fahadul (AUTHOR); Mitra, Saikat (AUTHOR); Nafady, Mohamed H. (AUTHOR); Rahman, Mohammad Tauhidur (AUTHOR); Tirth, Vineet (AUTHOR); Akter, Aklima (AUTHOR); Emran, Talha Bin (AUTHOR); Mohamed, Amany Abdel-Rahman (AUTHOR); Algahtani, Ali (AUTHOR); El-Kholy, Sanad S. (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 3/28/2022, p1-10. 10p. 9 Charts. - Source:
- Additional Information
- Subject Terms:
- Abstract: The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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