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9 a.m. - 8 p.m.
Phone: (843) 805-6930
West Ashley Library
9 a.m. - 7 p.m.
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Folly Beach Library
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Phone: (843) 588-2001
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
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Dorchester Road Library
9 a.m. - 8 p.m.
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John's Island Library
9 a.m. - 8 p.m.
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Wando Mount Pleasant Library
9 a.m. - 8 p.m.
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Analysis of Mitochondrial Network Morphology in Cultured Myoblasts from Patients with Mitochondrial Disorders.
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- Author(s): Sládková, J. (AUTHOR); Spáčilová, J. (AUTHOR); Čapek, M. (AUTHOR); Tesařová, M. (AUTHOR); Hansíková, H. (AUTHOR); Honzík, T. (AUTHOR); Martínek, J. (AUTHOR); Zámečník, J. (AUTHOR); Kostková, O. (AUTHOR); Zeman, J. (AUTHOR)
- Source:
Ultrastructural Pathology. Sep2015, Vol. 39 Issue 5, p340-350. 11p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Mitochondrial morphology was studied in cultivated myoblasts obtained from patients with mitochondrial disorders, including CPEO, MELAS and TMEM70 deficiency. Mitochondrial networks and ultrastructure were visualized by fluorescence microscopy and transmission electron microscopy, respectively. A heterogeneous picture of abnormally sized and shaped mitochondria with fragmentation, shortening, and aberrant cristae, lower density of mitochondria and an increased number of “megamitochondria” were found in patient myoblasts. Morphometric Fiji analyses revealed different mitochondrial network properties in myoblasts from patients and controls. The small number of cultivated myoblasts required for semiautomatic morphometric image analysis makes this tool useful for estimating mitochondrial disturbances in patients with mitochondrial disorders. [ABSTRACT FROM PUBLISHER]
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