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West Ashley Library
9 a.m. - 7 p.m.
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St. Paul's/Hollywood Library
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Evaluation of Ga-DOTA-TOC PET/CT for the detection of duodenopancreatic neuroendocrine tumors in patients with MEN1.
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- Author(s): Morgat, Clément; Vélayoudom-Céphise, Fritz-Line; Schwartz, Paul; Guyot, Martine; Gaye, Delphine; Vimont, Delphine; Schulz, Jürgen; Mazère, Joachim; Nunes, Marie-Laure; Smith, Denis; Hindié, Elif; Fernandez, Philippe; Tabarin, Antoine
- Source:
European Journal of Nuclear Medicine & Molecular Imaging. Jul2016, Vol. 43 Issue 7, p1258-1266. 9p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Context: Somatostatin receptor scintigraphy with In-pentetreotide (SRS) is used to detect duodenopancreatic neuroendocrine tumors (dpNETs) in multiple endocrine neoplasia type 1 (MEN1). However, SRS has limited sensitivity for this purpose. Positron emission tomography/computed tomography (PET/CT) with Ga-DOTA-TOC has a higher rate of sporadic dpNETs detection than SRS but there is little data for dpNETs detection in MEN1. Purpose: To compare the performances of Ga-DOTA-TOC PET/CT, SRS and contrast-enhanced computed tomography (CE-CT) to diagnose dpNETs in MEN1. Design and setting: Single-institution prospective comparative study Patients and methods: Nineteen consecutive MEN1 patients (aged 47 ± 13 years) underwent Ga-DOTA-TOC PET/CT, SRS, and CE-CT within 2 months in random order. Blinded readings of images were performed separately by experienced physicians. Unblinded analysis of CE-CT, combined with additional magnetic resonance imaging, endoscopic-ultrasound, F-2-fluoro-deoxy- d-glucose (F-FDG) PET/CT or histopathology results served as reference standard for dpNETs diagnosis. Results: The sensitivity of Ga-DOTA-TOC PET/CT, SRS, and CE-CT was 76, 20, and 60 %, respectively ( p < 0.0001). All the true-positive lesions detected by SRS were also depicted on Ga-DOTA-TOC PET/CT. Ga-DOTA-TOC PET/CT detected lesions of smaller size than SRS (10.7 ± 7.6 and 15.2 ± 5.9 mm, respectively, p < 0.03). False negatives of Ga-DOTA-TOC PET/CT included small dpNETs (<10 mm) and F-FDG PET/CT positive aggressive dpNETs. No false positives were recorded. In addition, whole-body mapping with Ga-DOTA-TOC PET/CT identified extra-abdominal MEN1-related tumors including one neuroendocrine thymic carcinoma identified by the three imaging procedures, one bronchial carcinoid undetected by CE-CT and three meningiomas undetected by SRS. Conclusions: Owing to higher diagnostic performance, Ga-DOTA-TOC PET/CT (or alternative Ga-labeled somatostatin analogues) should replace In-pentetreotide in the investigation of MEN1 patients. [ABSTRACT FROM AUTHOR]
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