Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential.

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  • Additional Information
    • Subject Terms:
    • Abstract:
      We characterized 55 influenza A(H9N2) viruses isolated in Pakistan during 2014-2016 and found that the hemagglutinin gene is of the G1 lineage and that internal genes have differentiated into a variety of novel genotypes. Some isolates had up to 4-fold reduction in hemagglutination inhibition titers compared with older viruses. Viruses with hemagglutinin A180T/V substitutions conveyed this antigenic diversity and also caused up to 3,500-fold greater binding to avian-like and >20-fold greater binding to humanlike sialic acid receptor analogs. This enhanced binding avidity led to reduced virus replication in primary and continuous cell culture. We confirmed that altered receptorbinding avidity of H9N2 viruses, including enhanced binding to human-like receptors, results in antigenic variation in avian influenza viruses. Consequently, current vaccine formulations might not induce adequate protective immunity in poultry, and emergence of isolates with marked avidity for human-like receptors increases the zoonotic risk. [ABSTRACT FROM AUTHOR]
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    • ISSN:
      1080-6040
    • DOI:
      10.3201/eid2501.180616
    • Accession Number:
      133711417
  • Citations
    • ABNT:
      SEALY, J. E. et al. Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential. Emerging Infectious Diseases, [s. l.], v. 25, n. 1, p. 63–72, 2019. Disponível em: . Acesso em: 18 jul. 2019.
    • AMA:
      Sealy JE, Yaqub T, Peacock TP, et al. Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential. Emerging Infectious Diseases. 2019;25(1):63-72. doi:10.3201/eid2501.180616.
    • APA:
      Sealy, J. E., Yaqub, T., Peacock, T. P., Pengxiang Chang, Ermetal, B., Clements, A., … Iqbal, M. (2019). Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential. Emerging Infectious Diseases, 25(1), 63–72. https://doi.org/10.3201/eid2501.180616
    • Chicago/Turabian: Author-Date:
      Sealy, Joshua E., Tahir Yaqub, Thomas P. Peacock, Pengxiang Chang, Burcu Ermetal, Anabel Clements, Jean-Remy Sadeyen, et al. 2019. “Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential.” Emerging Infectious Diseases 25 (1): 63–72. doi:10.3201/eid2501.180616.
    • Harvard:
      Sealy, J. E. et al. (2019) ‘Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential’, Emerging Infectious Diseases, 25(1), pp. 63–72. doi: 10.3201/eid2501.180616.
    • Harvard: Australian:
      Sealy, JE, Yaqub, T, Peacock, TP, Pengxiang Chang, Ermetal, B, Clements, A, Sadeyen, J-R, Mehboob, A, Shelton, H, Bryant, JE, Daniels, RS, McCauley, JW & Iqbal, M 2019, ‘Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential’, Emerging Infectious Diseases, vol. 25, no. 1, pp. 63–72, viewed 18 July 2019, .
    • MLA:
      Sealy, Joshua E., et al. “Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential.” Emerging Infectious Diseases, vol. 25, no. 1, Jan. 2019, pp. 63–72. EBSCOhost, doi:10.3201/eid2501.180616.
    • Chicago/Turabian: Humanities:
      Sealy, Joshua E., Tahir Yaqub, Thomas P. Peacock, Pengxiang Chang, Burcu Ermetal, Anabel Clements, Jean-Remy Sadeyen, et al. “Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential.” Emerging Infectious Diseases 25, no. 1 (January 2019): 63–72. doi:10.3201/eid2501.180616.
    • Vancouver/ICMJE:
      Sealy JE, Yaqub T, Peacock TP, Pengxiang Chang, Ermetal B, Clements A, et al. Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential. Emerging Infectious Diseases [Internet]. 2019 Jan [cited 2019 Jul 18];25(1):63–72. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=133711417