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West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
9 a.m. - 6 p.m.
Phone: (843) 883-3914
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
McClellanville Library
Closed for renovations
Phone: (843) 887-3699
Edisto Library
9 a.m. - 6 p.m.
Phone: (843) 869-2355
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Baxter-Patrick James Island
9 p.m. - 8 p.m.
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Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
Keith Summey North Charleston Library
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Phone: (843) 744-2489
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9 a.m. - 5 p.m.
Phone: (843) 805-6909
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Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro‐oesophageal reflux‐induced chronic cough.
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- Author(s): Dong, Ran; Xu, Xianghuai; Yu, Li; Ding, Hongmei; Pan, Jing; Yu, Yiming; Shi, Cuiqin; Chen, Qiang; Zhang, Mengru; Lv, Hanjing; Qiu, Zhongmin
- Source:
Alimentary Pharmacology & Therapeutics. Mar2019, Vol. 49 Issue 6, p714-722. 9p. 1 Diagram, 5 Charts, 3 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Summary: Background: Neuromodulators are considered potential therapeutic options for refractory gastro‐oesophageal reflux‐induced chronic cough. Aim: To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro‐oesophageal reflux‐induced chronic cough. Methods: Two hundred and thirty‐four patients with suspected refractory gastro‐oesophageal reflux‐induced chronic cough, who failed an 8‐week course of omeprazole and domperidone, were recruited into the open‐labelled study and randomly assigned to receive either gabapentin (maximum daily dose of 900 mg) or baclofen (maximum daily dose of 60 mg) for 8 weeks as add‐on therapy to the previous treatment. The primary end point was the successful rate of cough resolution; and the secondary end‐points included cough sensitivity to capsaicin and gastro‐oesophageal reflux disease questionnaire score and reported side effects. Results: One hundred and eleven patients in the gabapentin group and 106 in the baclofen group completed the study. The overall success rate for cough resolution was comparable (57.3% vs 53.0%, χ2 = 0.357, P = 0.550) between the two groups. In parallel, cough sensitivity to capsaicin and gastro‐oesophageal reflux disease questionnaire score decreased after treatment with either gabapentin or baclofen. However, gabapentin was associated with less frequent somnolence (20.5% vs 35.0%, χ2 = 6.156, P = 0.013) and dizziness (11.1% vs 23.9%, χ2 = 6.654, P = 0.010) than baclofen. Conclusions: Gabapentin and baclofen have similar therapeutic efficacy for suspected refractory gastro‐oesophageal reflux‐induced chronic cough. However, gabapentin may be preferable because of fewer side effects. Trial Register: http://www.chictr.org/; No.: ChiCTR‐ONC‐13003066. [ABSTRACT FROM AUTHOR]
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