Perioperative Management of the Direct-Acting Oral Anticoagulants.

THROMBOEMBOLISM prevention; BENZIMIDAZOLES; PYRIDINE; RIVAROXABAN; ANTICOAGULANTS; CELLULAR signal transduction; FIBRINOLYSIS; SURGICAL hemostasis; MEDICAL care costs; STROKE; WARFARIN; PERIOPERATIVE care; DISEASE complications; THERAPEUTICS

Since the 1950s, warfarin has been the most commonly prescribed anticoagulant in the prevention of stroke-related thromboembolism. Beginning in 2008, direct-acting oral anticoagulants (DOACs) began to replace warfarin. Although the DOACs had a greater safety profile, approved reversal agents for use in emergent/excessive hemorrhage did not exist. This course reviews the perioperative management of the DOACs. [ABSTRACT FROM AUTHOR]