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Real-time Visualization of Breast Carcinoma in Pathology Specimens From Patients Receiving Fluorescent Tumor-Marking Agent Tozuleristide.
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- Author(s): Dintzis, Suzanne M.; Hansen, Stacey; Harrington, Kristi M.; Tan, Lennart C.; Miller, Dennis M.; Ishak, Laura; Parrish-Novak, Julia; Kittle, David; Perry, Jeff; Gombotz, Carolyn; Fortney, Tina; Porenta, Stephanie; Hales, Lisa; Calhoun, Kristine E.; Anderson, Benjamin O.; Javid, Sara H.; Byrd, David R.
- Source:
Archives of Pathology & Laboratory Medicine. Sep2019, Vol. 143 Issue 9, p1076-1086. 8p. 4 Color Photographs, 3 Charts, 1 Graph. - Source:
- Additional Information
- Subject Terms: BREAST cancer diagnosis; BREAST cancer prognosis; BREAST tumor diagnosis; CANCER diagnosis; CANCER prognosis; ONCOLOGIC surgery; BREAST tumors; CANCER; CELL receptors; HISTOLOGICAL techniques; INTRAVENOUS therapy; MASTECTOMY; NONIONIZING radiation; INTRAOPERATIVE care; STAINS & staining (Microscopy); TUMOR markers; LUMPECTOMY; CARCINOMA in situ; DUCTAL carcinoma; PREOPERATIVE period; SURGICAL site; FLUORESCENT dyes; TUMOR grading
- Abstract: Context.--Resection of breast carcinoma with adequate margins reduces the risk of local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection and margin assessment. In this study, fluorescence imaging was conducted ex vivo on gross breast pathology specimens. Objectives.--To determine the potential of tozuleristide to detect breast carcinoma in fresh pathology specimens and the feasibility of fluorescence-guided intraoperative pathology assessment of surgical margins. Design.--Twenty-three patients received an intravenous bolus dose of 6 or 12 mg of tozuleristide at least 1 hour before surgery. Fifteen lumpectomy and 12 mastectomy specimens were evaluated for fluorescence by the site's clinical pathology staff using the SIRIS, an investigational near-infrared imaging device. The breast tissue was then processed per usual procedures. Fluorescent patterns were correlated with the corresponding hematoxylin-eosin--stained sections. Clinical pathology reports were used to correlate fluorescent signal to grade, histotype, prognostic marker status, and margin measurements. Results.--Tozuleristide fluorescence was readily observed in invasive and in situ breast carcinoma specimens. Most invasive carcinomas were bright and focal, whereas in situ lesions demonstrated a less intense, more diffuse pattern. Tozuleristide was detected in ductal and lobular carcinomas with a similar fluorescent pattern. Fluorescence was detected in high- and low-grade lesions, and molecular marker/hormone receptor status did not affect signal. Fluorescence could be used to identify the relationship of carcinoma to margins intraoperatively. Conclusions.--Tumor targeting with tozuleristide allowed visual real-time distinction between pathologically confirmed breast carcinoma and normal tissue. [ABSTRACT FROM AUTHOR]
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