Patterns of Cerebellar Connectivity with Intrinsic Connectivity Networks in Autism Spectrum Disorders.

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  • Author(s): Bednarz, Haley M.; Kana, Rajesh K.
  • Source:
    Journal of Autism & Developmental Disorders. Nov2019, Vol. 49 Issue 11, p4498-4514. 17p. 3 Illustrations, 1 Diagram, 5 Charts.
  • Additional Information
    • Subject Terms:
      CEREBELLUM physiology; AUTISM; CEREBRAL cortex; COGNITION; CASE-control method; EXECUTIVE function
    • Abstract:
      There is growing evidence of altered connectivity in autism spectrum disorders (ASD) between the cerebellum and cortex. Three intrinsic connectivity networks (ICNs) are especially important to cognitive processing in ASD: the default mode network (DMN), executive control network (ECN), and salience networks (SNs). The goal of this study was to compare resting-state functional connectivity between the cerebellum and the DMN, ECN, and SN in ASD and typically developing children (n = 74, ages 7–12 years). Children with ASD showed stronger connectivity between the ventral DMN and left cerebellar lobules I–IV. No meaningful relationships were observed between ICN-cerebellar functional connectivity and ASD symptoms. These results suggest that the cerebellum contributes to altered network connectivity in ASD. [ABSTRACT FROM AUTHOR]