The cellular repair of the brain in Parkinson's disease-past, present and future.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      Dopamine
      Parkinson's disease
      Stem cells
      Transplantation
      Xenografts
    • Abstract:
      Damage to the central nervous system was once considered irreparable. However, there is now growing optimism that neural transplant therapies may one day enable complete circuit reconstruction and thus functional benefit for patients with neurodegenerative conditions such as Parkinson's disease (PD), and perhaps even those with more widespread damage such as stroke patients. Indeed, since the late 1980s hundreds of patients with Parkinson's disease have received allografts of dopamine-rich embryonic human neural tissue. The grafted tissue has been shown to survive and ameliorate many of the symptoms of the disease, both in the clinical setting and in animal models of the disease. However, practical problems associated with tissue procurement and storage, and ethical concerns over using aborted human fetal tissue have fuelled a search for alternative sources of suitable material for grafting. In particular, stem cells and xenogeneic embryonic dopamine-rich neural tissue are being explored, both of which bring their own practical and ethical dilemmas. Here we review the progress made in neural transplantation, both in the laboratory and in the clinic with particular attention to the development of stem cell and xenogeneic tissue based therapy. [ABSTRACT FROM AUTHOR]
    • :
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    • ISSN:
      0966-3274
    • DOI:
      10.1016/j.trim.2003.12.012
    • Accession Number:
      14595479
  • Citations
    • ABNT:
      SAYLES, M.; JAIN, M.; BARKER, R. A. The cellular repair of the brain in Parkinson’s disease-past, present and future. Transplant Immunology, [s. l.], v. 12, n. 3–4, p. 321–342, 2004. DOI 10.1016/j.trim.2003.12.012. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=14595479. Acesso em: 24 out. 2020.
    • AMA:
      Sayles M, Jain M, Barker RA. The cellular repair of the brain in Parkinson’s disease-past, present and future. Transplant Immunology. 2004;12(3-4):321-342. doi:10.1016/j.trim.2003.12.012
    • APA:
      Sayles, M., Jain, M., & Barker, R. A. (2004). The cellular repair of the brain in Parkinson’s disease-past, present and future. Transplant Immunology, 12(3–4), 321–342. https://doi.org/10.1016/j.trim.2003.12.012
    • Chicago/Turabian: Author-Date:
      Sayles, Mark, Meena Jain, and Roger A. Barker. 2004. “The Cellular Repair of the Brain in Parkinson’s Disease-Past, Present and Future.” Transplant Immunology 12 (3–4): 321–42. doi:10.1016/j.trim.2003.12.012.
    • Harvard:
      Sayles, M., Jain, M. and Barker, R. A. (2004) ‘The cellular repair of the brain in Parkinson’s disease-past, present and future’, Transplant Immunology, 12(3–4), pp. 321–342. doi: 10.1016/j.trim.2003.12.012.
    • Harvard: Australian:
      Sayles, M, Jain, M & Barker, RA 2004, ‘The cellular repair of the brain in Parkinson’s disease-past, present and future’, Transplant Immunology, vol. 12, no. 3–4, pp. 321–342, viewed 24 October 2020, .
    • MLA:
      Sayles, Mark, et al. “The Cellular Repair of the Brain in Parkinson’s Disease-Past, Present and Future.” Transplant Immunology, vol. 12, no. 3–4, Apr. 2004, pp. 321–342. EBSCOhost, doi:10.1016/j.trim.2003.12.012.
    • Chicago/Turabian: Humanities:
      Sayles, Mark, Meena Jain, and Roger A. Barker. “The Cellular Repair of the Brain in Parkinson’s Disease-Past, Present and Future.” Transplant Immunology 12, no. 3–4 (April 2004): 321–42. doi:10.1016/j.trim.2003.12.012.
    • Vancouver/ICMJE:
      Sayles M, Jain M, Barker RA. The cellular repair of the brain in Parkinson’s disease-past, present and future. Transplant Immunology [Internet]. 2004 Apr [cited 2020 Oct 24];12(3–4):321–42. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=14595479