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Dynamic changes of exhaustion features in T cells during oral carcinogenesis.
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- Author(s): Xie, Wenqiang (AUTHOR); Shen, Jie (AUTHOR); Wang, Dikan (AUTHOR); Guo, Junyi (AUTHOR); Li, Qunxing (AUTHOR); Wen, Shuqiong (AUTHOR); Dai, Wenxiao (AUTHOR); Wen, Liling (AUTHOR); Lu, Huanzi (AUTHOR); Fang, Juan (AUTHOR); Wang, Zhi (AUTHOR)
- Source:
Cell Proliferation. Apr2022, Vol. 55 Issue 4, p1-12. 12p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Objectives: This study aimed to clarify the dynamic changes of exhaustion features in T cells during oral carcinogenesis. Materials and Methods: Mice were randomly divided into 4NQO group and control group. The exhaustion features of CD4+ and CD8+ T cells of both groups were detected by flow cytometry. Furthermore, multiplex immunohistochemistry was used to evaluate the expression of inhibitory receptors in human normal, dysplastic, and carcinogenesis tissues. Finally, anti‐PD‐1 antibody treatment was performed at the early premalignant phase of oral carcinogenesis. Results: The proportion of naive T cells in 4NQO group was lower than those in control group, while the proportion of effector memory T cells was higher in 4NQO group. The expression of inhibitory receptors on CD4+ and CD8+ T cells increased gradually during carcinogenesis. In contrast, the secretion of cytokines by CD4+ and CD8+ T cells decreased gradually with the progression stage. Strikingly, those changes occurred before the onset of oral carcinogenesis. The expression of inhibitory receptors on T cells increased gradually as the human tissues progressed from normal, dysplasia to carcinoma. Interestingly, PD‐1 blockade at the early premalignant phase could reverse carcinogenesis progression by restoring T cell function. Conclusions: T‐cell dysfunction was established at the early premalignant phase of oral carcinogenesis; PD‐1 blockade at the early premalignant phase can effectively reverse T‐cell exhaustion features and then prevent carcinogenesis progression. [ABSTRACT FROM AUTHOR]
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