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West Ashley Library
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Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection.
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- Author(s): Jonker, Pascal K. C. (AUTHOR); Metman, Madelon J. H. (AUTHOR); Sondorp, Luc H. J. (AUTHOR); Sywak, Mark S. (AUTHOR); Gill, Anthony J. (AUTHOR); Jansen, Liesbeth (AUTHOR); Links, Thera P. (AUTHOR); van Diest, Paul J. (AUTHOR); van Ginhoven, Tessa M. (AUTHOR); Löwik, Clemens W. G. M. (AUTHOR); Nguyen, Anh H. (AUTHOR); Coppes, Robert P. (AUTHOR); Robinson, Dominic J. (AUTHOR); van Dam, Gooitzen M. (AUTHOR); van Hemel, Bettien M. (AUTHOR); Fehrmann, Rudolf S. N. (AUTHOR); Kruijff, Schelto (AUTHOR)
- Source:
European Journal of Nuclear Medicine & Molecular Imaging. Aug2022, Vol. 49 Issue 10, p3557-3570. 14p. 2 Color Photographs, 1 Diagram, 3 Charts, 1 Graph. - Source:
- Additional Information
- Subject Terms:
- Abstract: Purpose: Patients undergoing prophylactic central compartment dissection (PCLND) for papillary thyroid cancer (PTC) are often overtreated. This study aimed to determine if molecular fluorescence-guided imaging (MFGI) and spectroscopy can be useful for detecting PTC nodal metastases (NM) and to identify negative central compartments intraoperatively. Methods: We used a data-driven prioritization strategy based on transcriptomic profiles of 97 primary PTCs and 80 normal thyroid tissues (NTT) to identify tumor-specific antigens for a clinically available near-infrared fluorescent tracer. Protein expression of the top prioritized antigen was immunohistochemically validated with a tissue microarray containing primary PTC (n = 741) and NTT (n = 108). Staining intensity was correlated with 10-year locoregional recurrence-free survival (LRFS). A phase 1 study (NCT03470259) with EMI-137, targeting MET, was conducted to evaluate safety, optimal dosage for detecting PTC NM with MFGI, feasibility of NM detection with quantitative fiber-optic spectroscopy, and selective binding of EMI-137 for MET. Results: MET was selected as the most promising antigen. A worse LRFS was observed in patients with positive versus negative MET staining (81.9% versus 93.2%; p = 0.02). In 19 patients, no adverse events related to EMI-137 occurred. 0.13 mg/kg EMI-137 was selected as optimal dosage for differentiating NM from normal lymph nodes using MFGI (p < 0.0001) and spectroscopy (p < 0.0001). MFGI identified 5/19 levels (26.3%) without NM. EMI-137 binds selectively to MET. Conclusion: MET is overexpressed in PTC and associated with increased locoregional recurrence rates. Perioperative administration of EMI-137 is safe and facilitates NM detection using MFGI and spectroscopy, potentially reducing the number of negative PCLNDs with more than 25%. Clinical trial registration.: NCT03470259. [ABSTRACT FROM AUTHOR]
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