The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      apoptosis
      brain
      Hsp27
      Hsp70
      hyperthermia
      ischemia
      neuroprotection
    • Abstract:
      Heat shock proteins (Hsps) are highly conserved and under physiological conditions act as molecular chaperones and/or have anti-apoptotic activities. Expression in the brain of two heat shock proteins, the70  kDa Hsp (Hsp70) and the 27  kDa Hsp (Hsp27), is notable because both proteins are highly inducible in glial cells and neurons following a wide range of noxious stimuli including ischemia, epileptic seizure and hyperthermia. In the central nervous system, constitutive expression of Hsp27 is limited to many (but not all) sensory and motor neurons of the brain stem and spinal cord, while there is little or no constitutive expression of Hsp70. However, inducible expression of both Hsp70 and Hsp27 is present in many areas of the brain and retina and is associated with cellular resistance to a variety of insults. The potential for manipulating the expression levels of Hsps for therapeutic advantage in neurodegenerative diseases such as Alzheimer's disease, stroke and glaucoma will be explored. [ABSTRACT FROM AUTHOR]
    • :
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    • ISSN:
      0265-6736
    • DOI:
      10.1080/02656730500069955
    • Accession Number:
      17718068
  • Citations
    • ABNT:
      FRANKLIN, T. B. et al. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. International Journal of Hyperthermia, [s. l.], v. 21, n. 5, p. 379–392, 2005. Disponível em: . Acesso em: 24 ago. 2019.
    • AMA:
      Franklin TB, Krueger-Naug AM, Clarke DB, Arrigo A-P, Currie RW. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. International Journal of Hyperthermia. 2005;21(5):379-392. doi:10.1080/02656730500069955.
    • APA:
      Franklin, T. B., Krueger-Naug, A. M., Clarke, D. B., Arrigo, A.-P., & Currie, R. W. (2005). The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. International Journal of Hyperthermia, 21(5), 379–392. https://doi.org/10.1080/02656730500069955
    • Chicago/Turabian: Author-Date:
      Franklin, T. B., A. M. Krueger-Naug, D. B. Clarke, A.-P. Arrigo, and R. W. Currie. 2005. “The Role of Heat Shock Proteins Hsp70 and Hsp27 in Cellular Protection of the Central Nervous System.” International Journal of Hyperthermia 21 (5): 379–92. doi:10.1080/02656730500069955.
    • Harvard:
      Franklin, T. B. et al. (2005) ‘The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system’, International Journal of Hyperthermia, 21(5), pp. 379–392. doi: 10.1080/02656730500069955.
    • Harvard: Australian:
      Franklin, TB, Krueger-Naug, AM, Clarke, DB, Arrigo, A-P & Currie, RW 2005, ‘The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system’, International Journal of Hyperthermia, vol. 21, no. 5, pp. 379–392, viewed 24 August 2019, .
    • MLA:
      Franklin, T. B., et al. “The Role of Heat Shock Proteins Hsp70 and Hsp27 in Cellular Protection of the Central Nervous System.” International Journal of Hyperthermia, vol. 21, no. 5, Aug. 2005, pp. 379–392. EBSCOhost, doi:10.1080/02656730500069955.
    • Chicago/Turabian: Humanities:
      Franklin, T. B., A. M. Krueger-Naug, D. B. Clarke, A.-P. Arrigo, and R. W. Currie. “The Role of Heat Shock Proteins Hsp70 and Hsp27 in Cellular Protection of the Central Nervous System.” International Journal of Hyperthermia 21, no. 5 (August 2005): 379–92. doi:10.1080/02656730500069955.
    • Vancouver/ICMJE:
      Franklin TB, Krueger-Naug AM, Clarke DB, Arrigo A-P, Currie RW. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. International Journal of Hyperthermia [Internet]. 2005 Aug [cited 2019 Aug 24];21(5):379–92. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=17718068