Growth in children with chronic kidney disease: a report from the Chronic Kidney Disease in Children Study.

ANTHROPOMETRY; CHI-squared test; CHRONIC kidney failure; CONFIDENCE intervals; FISHER exact test; GLOMERULAR filtration rate; HUMAN growth; LONGITUDINAL method; MEDICAL cooperation; PEDIATRICS; REGRESSION analysis; RESEARCH; RESEARCH funding; STATISTICS; DATA analysis; DESCRIPTIVE statistics

Background: Growth failure is common among children with chronic kidney disease (CKD). We examined the relationship of growth parameters with glomerular filtration rate (GFR), CKD diagnosis, sex and laboratory results in children with CKD. Methods: Baseline data from 799 children (median age 11.0 years, median GFR 49.9 mL/min/1.73 m) participating in the Chronic Kidney Disease in Children Study were examined. Growth was quantified by age-sex-specific height, weight, body mass index (BMI-age), and height-age-sex-specific BMI (BMI-height-age) standard deviation scores (SDS). Results: Median height and weight SDS were −0.55 [interquartile range (IQR) −1.35 to 0.19] and 0.03 (IQR −0.82 to 0.97), respectively. Girls with non-glomerular CKD were the shortest (median height SDS −0.83; IQR −1.62 to −0.02). Compared to those with a serum bicarbonate (CO) level of ≥22 mEq/L, children with CO of <18 mEq/L had a height SDS that was on average 0.67 lower [95 % confidence interval (CI) −0.31 to −1.03]. Only 23 % of children with a height SDS of ≤−1.88 were prescribed growth hormone therapy. Forty-six percent of children with glomerular CKD were overweight or obese (BMI-height-age ≥85th percentile). Conclusions: Growth outcomes in a contemporary cohort of children with CKD remain suboptimal. Interventions targeting metabolic acidosis and overcoming barriers to recombinant human growth hormone usage may improve growth in this population. [ABSTRACT FROM AUTHOR]