Presentation and outcome of paediatric membranous non-proliferative lupus nephritis.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      Children
      Class V nephritis
      Membranous glomerulonephritis
      Outcome
      Systemic lupus erythematosus
      Treatment
    • Abstract:
      Background: Studies of paediatric patients with membranous lupus nephritis (MLN) have yielded variable results, mostly due to the inclusion of mixed, i.e. proliferative nephritis. The aim of this study was to describe clinical and laboratory findings at the diagnosis of paediatric non-proliferative MLN, report the outcome and identify predictors of remission. Methods: A single-center cohort study of consecutive children diagnosed with non-proliferative MLN was performed. Clinical and laboratory measures and treatment regimens were obtained in prospective standardized assessments. Renal outcome was measured by renal parameters and steroid requirement. Predictors for remission and time to remission were determined. Results: A total of 30 children were identified with a median follow-up time 4.1 years. Of 21 patients followed for more than 2 years, 19 (90 %) achieved clinical remission, and 16 (76 %) achieved a state of maintained clinical remission on low-dose prednisone. Three patients developed proliferative nephritis on subsequent renal biopsy. Lower albumin at the time of biopsy was correlated with a lower rate of remission and longer time to remission. Conclusions: Among our paediatric patient cohort the outcome of non-proliferative MLN in systemic lupus erythematosus was good. The majority of patients did not require aggressive immunosuppressive treatment to reach a stable disease state on low-dose steroid treatment. [ABSTRACT FROM AUTHOR]
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    • ISSN:
      0931-041X
    • DOI:
      10.1007/s00467-014-2908-2
    • Accession Number:
      99597611
  • Citations
    • ABNT:
      HUGLE, B. et al. Presentation and outcome of paediatric membranous non-proliferative lupus nephritis. Pediatric Nephrology, [s. l.], v. 30, n. 1, p. 113–121, 2015. Disponível em: . Acesso em: 17 ago. 2019.
    • AMA:
      Hugle B, Silverman E, Tyrrell P, Harvey E, Hébert D, Benseler S. Presentation and outcome of paediatric membranous non-proliferative lupus nephritis. Pediatric Nephrology. 2015;30(1):113-121. doi:10.1007/s00467-014-2908-2.
    • APA:
      Hugle, B., Silverman, E., Tyrrell, P., Harvey, E., Hébert, D., & Benseler, S. (2015). Presentation and outcome of paediatric membranous non-proliferative lupus nephritis. Pediatric Nephrology, 30(1), 113–121. https://doi.org/10.1007/s00467-014-2908-2
    • Chicago/Turabian: Author-Date:
      Hugle, Boris, Earl Silverman, Pascal Tyrrell, Elizabeth Harvey, Diane Hébert, and Susanne Benseler. 2015. “Presentation and Outcome of Paediatric Membranous Non-Proliferative Lupus Nephritis.” Pediatric Nephrology 30 (1): 113–21. doi:10.1007/s00467-014-2908-2.
    • Harvard:
      Hugle, B. et al. (2015) ‘Presentation and outcome of paediatric membranous non-proliferative lupus nephritis’, Pediatric Nephrology, 30(1), pp. 113–121. doi: 10.1007/s00467-014-2908-2.
    • Harvard: Australian:
      Hugle, B, Silverman, E, Tyrrell, P, Harvey, E, Hébert, D & Benseler, S 2015, ‘Presentation and outcome of paediatric membranous non-proliferative lupus nephritis’, Pediatric Nephrology, vol. 30, no. 1, pp. 113–121, viewed 17 August 2019, .
    • MLA:
      Hugle, Boris, et al. “Presentation and Outcome of Paediatric Membranous Non-Proliferative Lupus Nephritis.” Pediatric Nephrology, vol. 30, no. 1, Jan. 2015, pp. 113–121. EBSCOhost, doi:10.1007/s00467-014-2908-2.
    • Chicago/Turabian: Humanities:
      Hugle, Boris, Earl Silverman, Pascal Tyrrell, Elizabeth Harvey, Diane Hébert, and Susanne Benseler. “Presentation and Outcome of Paediatric Membranous Non-Proliferative Lupus Nephritis.” Pediatric Nephrology 30, no. 1 (January 2015): 113–21. doi:10.1007/s00467-014-2908-2.
    • Vancouver/ICMJE:
      Hugle B, Silverman E, Tyrrell P, Harvey E, Hébert D, Benseler S. Presentation and outcome of paediatric membranous non-proliferative lupus nephritis. Pediatric Nephrology [Internet]. 2015 Jan [cited 2019 Aug 17];30(1):113–21. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=99597611