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Protein carbonyl group content in patients affected by familiar chronic nail candidiasis.
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- Author(s): Gangemi S;Gangemi S; Saija A; Tomaino A; Cimino F; Merendino RA; Minciullo PL; Briuglia S; Merlino MV; Dallapiccola B; Ferlazzo B; Salpietro DC
- Source:
Mediators of inflammation [Mediators Inflamm] 2003 Aug; Vol. 12 (4), pp. 247-9.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 9209001 Publication Model: Print Cited Medium: Print ISSN: 0962-9351 (Print) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE
- Publication Information: Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992- - Subject Terms:
- Abstract: Familiar chronic nail candidiasis (FCNC) is a rare disorder characterized by early-onset infections caused by different species of Candida, restricted to the nail of the hands and feet, and associated with a low serum concentration of intercellular adhesion molecule 1. Host defense mechanisms against candidiasis require the cooperation of many immune cells through several candidacidal mechanisms, including oxygen-dependent killing mechanisms, mediated by a superoxide anion radical myeloperoxidase--H2O2--halide system, and reactive nitrogen intermediates. We analyzed protein carbonyl groups (considered a useful marker of oxidative stress) in the serum of patients belonging to a five-generation Italian family with an isolated form of FCNC. Serum protein carbonyl groups in FCNC patients were significantly lower than those measured in healthy donors. Also, if this hypothesis is merely speculative, we could suggest that the decreased circulating level of protein carbonyl groups in these patients is not a marker of a lower oxidative stress condition, but might be linked to a lower protease activity.
- References: J Infect Dis. 1996 Aug;174(2):435-9. (PMID: 8699084)
Infect Immun. 2001 Jun;69(6):3939-46. (PMID: 11349062)
J Med Genet. 2002 Sep;39(9):671-5. (PMID: 12205111)
Eur J Hum Genet. 2003 Jun;11(6):433-6. (PMID: 12774035)
J Med Genet. 1972 Sep;9(3):302-10. (PMID: 4562433) - Accession Number: 0 (Biomarkers)
0 (Blood Proteins)
11062-77-4 (Superoxides)
126547-89-5 (Intercellular Adhesion Molecule-1) - Publication Date: Date Created: 20030930 Date Completed: 20040720 Latest Revision: 20181113
- Publication Date: 20240104
- Accession Number: PMC1781615
- Accession Number: 10.1080/09629350310001599693
- Accession Number: 14514476
- Source:
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