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Chagas' disease diagnosis: comparative analysis of recombinant ELISA with conventional ELISA and the haemagglutination test.
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- Author(s): Gadelha AA;Gadelha AA; Verçosa AF; Lorena VM; Nakazawa M; Carvalho AB; Souza WV; Ferreira AG; Silva ED; Krieger MA; Goldenberg S; Gomes YM
- Source:
Vox sanguinis [Vox Sang] 2003 Oct; Vol. 85 (3), pp. 165-70.- Publication Type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Blackwell Science Country of Publication: England NLM ID: 0413606 Publication Model: Print Cited Medium: Print ISSN: 0042-9007 (Print) Linking ISSN: 00429007 NLM ISO Abbreviation: Vox Sang Subsets: MEDLINE
- Publication Information: Publication: 2001- : Oxford, UK : Blackwell Science
Original Publication: Basel : Karger - Subject Terms: Antibodies, Protozoan/*blood ; Chagas Disease/*diagnosis ; Chagas Disease/*immunology ; Enzyme-Linked Immunosorbent Assay/*methods ; Hemagglutination Tests/*methods ; Trypanosoma cruzi/*immunology; Adult ; Aged ; Aged, 80 and over ; Animals ; Antigens, Protozoan ; Case-Control Studies ; Diagnostic Errors ; Enzyme-Linked Immunosorbent Assay/statistics & numerical data ; Hemagglutination Tests/statistics & numerical data ; Humans ; Middle Aged ; Protozoan Proteins/immunology ; Recombinant Proteins/immunology ; Sensitivity and Specificity
- Abstract: Background and Objectives: Serological screening for Chagas' disease in the blood banks of South America is carried out by using two different assays that generally show a high number of inconclusive results. To establish a combination of two tests that can minimize the number of inconclusive results, we compared a recombinant enzyme-linked immunosorbent assay (ELISA) with two conventional tests.
Materials and Methods: Serum samples from chagasic patients (n = 112), from non-chagasic individuals (n = 143) and from patients with other diseases (n = 32) were tested using three assays: recombinant ELISA (Rec-ELISA); conventional ELISA (Con-ELISA); and the indirect haemagglutination (IHA) test.
Results: When we evaluated the data by matching the Rec-ELISA and the IHA test, 52 inconclusive results were obtained. When Rec-ELISA and Con-ELISA were matched, only four inconclusive results were observed.
Conclusions: Our investigation indicates that the use of two ELISAs with different antigen preparations provides an effective test combination for blood bank screening of Chagas' disease.
(Copyright 2003 Blackwell Publishing) - Accession Number: 0 (Antibodies, Protozoan)
0 (Antigens, Protozoan)
0 (Protozoan Proteins)
0 (Recombinant Proteins) - Publication Date: Date Created: 20031001 Date Completed: 20050207 Latest Revision: 20190819
- Publication Date: 20240104
- Accession Number: 10.1046/j.1423-0410.2003.00340.x
- Accession Number: 14516446
- Source:
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