Fatigue mechanisms in patients with cancer: effects of tumor necrosis factor and exercise on skeletal muscle.

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  • Author(s): St Pierre BA;St Pierre BA; Kasper CE; Lindsey AM
  • Source:
    Oncology nursing forum [Oncol Nurs Forum] 1992 Apr; Vol. 19 (3), pp. 419-25.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oncology Nursing Society Country of Publication: United States NLM ID: 7809033 Publication Model: Print Cited Medium: Print ISSN: 0190-535X (Print) Linking ISSN: 0190535X NLM ISO Abbreviation: Oncol Nurs Forum Subsets: MEDLINE
    • Publication Information:
      Publication: Pittsburgh, PA : Oncology Nursing Society
      Original Publication: New York, Oncology Nursing Society.
    • Subject Terms:
    • Abstract:
      Fatigue is a common adverse effect of cancer and its therapy. However, the specific mechanisms underlying cancer fatigue are unclear. One physiologic mechanism may involve changes in skeletal muscle protein stores or metabolite concentration. A reduction in skeletal muscle protein stores may result from endogenous tumor necrosis factor (TNF) or from TNF administered as antineoplastic therapy. This muscle wasting would require patients to exert an unusually high amount of effort to generate adequate contractile force during exercise performance or during extended periods of sitting or standing. This additional effort could result in the onset of fatigue. Additionally, cancer fatigue may develop or become exacerbated during exercise as a consequence of changes in the concentration of skeletal muscle metabolites. These biochemical alterations may interfere with force that is produced by the muscle contractile proteins. These physiologic changes may play a role in the decision to include exercise in the rehabilitation plans of patients with cancer. They also may affect ideas about fatigue.
    • Number of References:
      34
    • Grant Information:
      NR02204 United States NR NINR NIH HHS; NR06503 United States NR NINR NIH HHS
    • Contributed Indexing:
      Investigator: CE Kasper, U CA, Los Angeles
      Keywords: NASA Discipline Cell Biology; Non-NASA Center
    • Accession Number:
      0 (Tumor Necrosis Factor-alpha)
    • Publication Date:
      Date Created: 19920401 Date Completed: 19920701 Latest Revision: 20220330
    • Publication Date:
      20240104
    • Accession Number:
      1594464