Can the immune system be harnessed to repair the CNS?

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  • Author(s): Popovich PG;Popovich PG; Longbrake EE
  • Source:
    Nature Reviews. Neuroscience [Nat Rev Neurosci] 2008 Jun; Vol. 9 (6), pp. 481-93.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962781 Publication Model: Print Cited Medium: Internet ISSN: 1471-0048 (Electronic) Linking ISSN: 1471003X NLM ISO Abbreviation: Nat. Rev. Neurosci. Subsets: MEDLINE
    • Publication Information:
      Original Publication: London, UK : Nature Pub. Group,
    • Subject Terms:
    • Abstract:
      Experimental and clinical data have demonstrated that activating the immune system in the CNS can be destructive. However, other studies have shown that enhancing an immune response can be therapeutic, and several clinical trials have been initiated with the aim of boosting immune responses in the CNS of individuals with spinal cord injury, multiple sclerosis and Alzheimer's disease. Here, we evaluate the controversies in the field and discuss the remaining scientific challenges that are associated with enhancing immune function in the CNS to treat neurological diseases.
    • Number of References:
      293
    • Publication Date:
      Date Created: 20080521 Date Completed: 20080616 Latest Revision: 20080520
    • Publication Date:
      20181210
    • Accession Number:
      10.1038/nrn2398
    • Accession Number:
      18490917
  • Citations
    • ABNT:
      POPOVICH, P. G.; LONGBRAKE, E. E. Can the immune system be harnessed to repair the CNS? Nature Reviews. Neuroscience, [s. l.], v. 9, n. 6, p. 481–493, 2008. DOI 10.1038/nrn2398. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=18490917. Acesso em: 19 fev. 2020.
    • AMA:
      Popovich PG, Longbrake EE. Can the immune system be harnessed to repair the CNS? Nature Reviews Neuroscience. 2008;9(6):481-493. doi:10.1038/nrn2398.
    • APA:
      Popovich, P. G., & Longbrake, E. E. (2008). Can the immune system be harnessed to repair the CNS? Nature Reviews. Neuroscience, 9(6), 481–493. https://doi.org/10.1038/nrn2398
    • Chicago/Turabian: Author-Date:
      Popovich, Phillip G, and Erin E Longbrake. 2008. “Can the Immune System Be Harnessed to Repair the CNS?” Nature Reviews. Neuroscience 9 (6): 481–93. doi:10.1038/nrn2398.
    • Harvard:
      Popovich, P. G. and Longbrake, E. E. (2008) ‘Can the immune system be harnessed to repair the CNS?’, Nature Reviews. Neuroscience, 9(6), pp. 481–493. doi: 10.1038/nrn2398.
    • Harvard: Australian:
      Popovich, PG & Longbrake, EE 2008, ‘Can the immune system be harnessed to repair the CNS?’, Nature Reviews. Neuroscience, vol. 9, no. 6, pp. 481–493, viewed 19 February 2020, .
    • MLA:
      Popovich, Phillip G., and Erin E. Longbrake. “Can the Immune System Be Harnessed to Repair the CNS?” Nature Reviews. Neuroscience, vol. 9, no. 6, June 2008, pp. 481–493. EBSCOhost, doi:10.1038/nrn2398.
    • Chicago/Turabian: Humanities:
      Popovich, Phillip G, and Erin E Longbrake. “Can the Immune System Be Harnessed to Repair the CNS?” Nature Reviews. Neuroscience 9, no. 6 (June 2008): 481–93. doi:10.1038/nrn2398.
    • Vancouver/ICMJE:
      Popovich PG, Longbrake EE. Can the immune system be harnessed to repair the CNS? Nature Reviews Neuroscience [Internet]. 2008 Jun [cited 2020 Feb 19];9(6):481–93. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=18490917