Antihyperglycemic effect of Trigonella foenum-graecum (fenugreek) seed extract in alloxan-induced diabetic rats and its use in diabetes mellitus: a brief qualitative phytochemical and acute toxicity test on the extract.

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  • Author(s): Mowla A;Mowla A; Alauddin M; Rahman MA; Ahmed K
  • Source:
    African journal of traditional, complementary, and alternative medicines : AJTCAM [Afr J Tradit Complement Altern Med] 2009 May 07; Vol. 6 (3), pp. 255-61. Date of Electronic Publication: 2009 May 07.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: African Traditional Herbal Medicine Supporters Initiative Country of Publication: Nigeria NLM ID: 101232990 Publication Model: Electronic Cited Medium: Internet ISSN: 2505-0044 (Electronic) Linking ISSN: 25050044 NLM ISO Abbreviation: Afr J Tradit Complement Altern Med Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Osun : African Traditional Herbal Medicine Supporters Initiative
      Original Publication: [Ile-Ife, Nigeria? : African Networks on Ethnomedicines, 2004]-
    • Subject Terms:
      Phytotherapy*; Diabetes Mellitus/*drug therapy ; Diabetes Mellitus, Experimental/*drug therapy ; Hypoglycemic Agents/*pharmacology ; Trigonella/*chemistry; Administration, Oral ; Animals ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Dose-Response Relationship, Drug ; Female ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/toxicity ; Male ; Mice ; Rats ; Rats, Wistar ; Seeds/chemistry ; Sulfonylurea Compounds/pharmacology ; Sulfonylurea Compounds/therapeutic use ; Toxicity Tests, Acute ; Trigonella/toxicity
    • Abstract:
      The effects of ethanol extract of Trigonella foenum-graecum (Fenugreek) seeds on the blood glucose levels in alloxan-induced diabetic rats at different doses (2 g/kg, 1 g/kg, 0.5 g/kg and 0.1 g/kg) were studied. The hypoglycemic effect of extract was compared with that of the standard antidiabetic drug (glimepiride, 4 mg/kg) single dose. The extract showed significant activity against the diabetic state induced by alloxan but the intensity of hypoglycemic effect varied from dose to dose. The most effective dose recognized was 1 g/kg but that is still lower than the standard antidiabetic drug. No acute toxicity was observed for ethanol extract of T. foenum-graecum seed when it was administered orally at high dose level (3 g/kg body weight), which is higher than effective antihyperglycemic dose, and closely observed for 24 hrs for any mortality and next 10 days for any delayed toxic effects on gross behavioral activities. Phytochemical group tests were also accomplished and presence of alkaloids, steroids and carbohydrates were recognized in the extract.
    • References:
      Diabetes. 1998 Mar;47(3):345-51. (PMID: 9519738)
      Diabetes. 1991 Apr;40(4):405-12. (PMID: 2010041)
      Eur J Clin Nutr. 1988 Jan;42(1):51-4. (PMID: 3286242)
      Cell Biol Int. 2001;25(3):227-37. (PMID: 11352495)
      Physiol Res. 2001;50(6):537-46. (PMID: 11829314)
      Drugs. 1981 Sep;22(3):211-45. (PMID: 7021124)
      Diabetes. 1984 Oct;33(10):1008-11. (PMID: 6383903)
      J Biochem Mol Biol Biophys. 2002 Aug;6(4):289-92. (PMID: 12186747)
      J Assoc Physicians India. 2001 Nov;49:1057-61. (PMID: 11868855)
      Eur J Clin Nutr. 1990 Apr;44(4):301-6. (PMID: 2194788)
      Drugs. 1995 Mar;49(3):345-61. (PMID: 7774511)
      Br J Nutr. 2007 Mar;97(3):514-21. (PMID: 17313713)
      J Ethnopharmacol. 2003 Sep;88(1):73-7. (PMID: 12902054)
      J Altern Complement Med. 2007 Dec;13(10):1135-50. (PMID: 18166127)
      Cancer Epidemiol Biomarkers Prev. 2004 Aug;13(8):1392-8. (PMID: 15298963)
      J Med Food. 2004 Summer;7(2):153-6. (PMID: 15298761)
      Eur J Pharmacol. 2000 Mar 3;390(3):339-45. (PMID: 10708743)
      Planta Med. 1988 Aug;54(4):286-90. (PMID: 3222370)
      Arch Int Pharmacodyn Ther. 1974 Jul;210(1):27-37. (PMID: 4280278)
      Asia Pac J Clin Nutr. 2007;16 Suppl 1:422-6. (PMID: 17392143)
    • Contributed Indexing:
      Keywords: alkaloid; alloxan; hypoglycemic effect; phytochemical test; toxicity
    • Accession Number:
      0 (Blood Glucose)
      0 (Hypoglycemic Agents)
      0 (Sulfonylurea Compounds)
      6KY687524K (glimepiride)
    • Publication Date:
      Date Created: 20100508 Date Completed: 20100622 Latest Revision: 20220408
    • Publication Date:
      20240104
    • Accession Number:
      PMC2816457
    • Accession Number:
      10.4314/ajtcam.v6i3.57165
    • Accession Number:
      20448850