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The cyclooxygenase-1 C50T polymorphism is not associated with aspirin responsiveness status in stable coronary artery disease in Tunisian patients.
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- Author(s): Chakroun T;Chakroun T; Addad F; Yacoub S; Abderrezak F; Gerotziafas GT; Abdelkafi S; Hassine M; Gamra H; Hatmi M; Elalamy I
- Source:
Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2011 Jul-Aug; Vol. 15 (7-8), pp. 513-6. Date of Electronic Publication: 2011 Mar 24.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101494210 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-0257 (Electronic) Linking ISSN: 19450257 NLM ISO Abbreviation: Genet Test Mol Biomarkers Subsets: MEDLINE
- Publication Information: Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
- Subject Terms: Drug Resistance* ; Polymorphism, Genetic*; Aspirin/*pharmacology ; Blood Platelets/*drug effects ; Coronary Artery Disease/*drug therapy ; Cyclooxygenase 1/*genetics; Aspirin/therapeutic use ; Coronary Artery Disease/genetics ; Humans ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Thromboxane B2/analogs & derivatives ; Thromboxane B2/urine ; Tunisia
- Abstract: In this study, we evaluate the relationships between aspirin nonresponsiveness and the cyclooxygenase-1 (Cox-1) gene C50T polymorphism in stable coronary artery disease (CAD) in Tunisian patients. One hundred twenty-five stable CAD patients were included. The Cox-1 gene C50T polymorphism was determined by the polymerase chain reaction/restriction fragment length polymorphism method. Aspirin response was evaluated by measuring the collagen epinephrine closer time and the urinary dehydro-thromboxane B2 excretion. According to the collagen epinephrine closer time values, the frequency of the -50T allele was not significantly different in bad responders when compared with good responders (36.8% vs. 15.7%; p=0.1). Similarly, the presence of the -50T mutant allele was not statistically different comparing bad and good responders according to the urinary 11-dehydro-thromboxane B2 excretion concentration (60% vs. 40%; p=0.43). Our study did not demonstrate any association between the Cox-1 gene C50T polymorphism and aspirin nonresponsiveness status in stable CAD patients.
- Accession Number: 54397-85-2 (Thromboxane B2)
67910-12-7 (11-dehydro-thromboxane B2)
EC 1.14.99.1 (Cyclooxygenase 1)
R16CO5Y76E (Aspirin) - Publication Date: Date Created: 20110326 Date Completed: 20111115 Latest Revision: 20160511
- Publication Date: 20240104
- Accession Number: 10.1089/gtmb.2010.0225
- Accession Number: 21434767
- Source:
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