Auditory evoked potentials remain abnormal after CPAP treatment in patients with severe obstructive sleep apnoea.

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  • Author(s): Vakulin A;Vakulin A; Catcheside PG; Baulk SD; Antic NA; van den Heuvel CJ; Banks S; McEvoy RD
  • Source:
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2012 Feb; Vol. 123 (2), pp. 310-7. Date of Electronic Publication: 2011 Aug 06.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100883319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8952 (Electronic) Linking ISSN: 13882457 NLM ISO Abbreviation: Clin Neurophysiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier, c1999-
    • Subject Terms:
      Continuous Positive Airway Pressure*/methods ; Severity of Illness Index*; Evoked Potentials, Auditory/*physiology ; Sleep Apnea, Obstructive/*physiopathology ; Sleep Apnea, Obstructive/*therapy; Acoustic Stimulation/methods ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Treatment Outcome
    • Abstract:
      Objective: To assess the effects of 3 months of optimal CPAP treatment on auditory event related potentials (AERP) in patients with severe obstructive sleep apnoea (OSA) compared with healthy controls.
      Methods: Auditory odd-ball related N1, P2, N2 and P3 AERP components were assessed in 9 severe OSA subjects and 9 healthy controls at baseline evaluation and at ∼3 months follow-up in both groups, with OSA subjects treated with continuous positive air-way pressure (CPAP) during this period.
      Results: Severe OSA subjects showed significantly delayed, P2, N2 and P3 latencies, and significantly different P2 and P3 amplitudes compared to controls at baseline (group effect, all p<0.05). At follow-up evaluation P3 latency shortened in treated OSA patients but remained prolonged compared to controls (group by treatment interaction, p<0.05) despite high CPAP compliance (6h/night). The earlier AERP (P2 and N2) components did not change in either controls or OSA patients at follow-up and remained different in patients versus controls.
      Conclusions: This study demonstrates that in severe OSA patients AERP responses show minimal or no improvement and remain abnormal following 3 months of optimal CPAP treatment.
      Significance: Persistent cortical sensory processing abnormalities despite treatment in severe OSA may have implications for daytime neurobehavioral performance and safety in OSA patients. AERP responses may help identify residual performance deficits and risks.
      (Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
    • Publication Date:
      Date Created: 20110809 Date Completed: 20120227 Latest Revision: 20120113
    • Publication Date:
      20240104
    • Accession Number:
      10.1016/j.clinph.2011.07.004
    • Accession Number:
      21821469