Parasite antigens recognized by patients with cutaneous leishmaniasis.

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  • Author(s): Jaffe CL;Jaffe CL; Shor R; Trau H; Passwell JH
  • Source:
    Clinical and experimental immunology [Clin Exp Immunol] 1990 Apr; Vol. 80 (1), pp. 77-82.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104 (Print) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
    • Publication Information:
      Publication: 2022- : Oxford : Oxford University Press
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Antigens, Protozoan/*immunology ; Leishmania tropica/*immunology ; Leishmaniasis/*immunology ; Lymphocyte Activation/*immunology; Animals ; Antibodies, Protozoan/immunology ; Blotting, Western ; Humans ; T-Lymphocytes/immunology
    • Abstract:
      Humoral and cell-mediated responses to crude and purified parasite antigens were examined in patients with active cutaneous leishmaniasis caused by Leishmania major. The patients had serum antibody titres against parasite lysates ranging from 1/500 to 1/10,000 and recognized multiple components by Western blotting with molecular weights between 5000 and greater than 200,000. Several components, particularly at 5 and 50 kD, were recognized by most of the patients. The lymphoproliferative responses to two pure antigens, promastigote surface protease and lipophosphoglycan, both considered potential candidates for the development of a human vaccine were measured. No response to promastigote surface protease was observed even at 10 micrograms/ml; however, weak proliferation to lipophosphoglycan was consistently present. T cell blots examining peripheral blood lymphocyte proliferation, showed antigen-specific responses to a 72-82 kD component in promastigote lysates.
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    • Accession Number:
      0 (Antibodies, Protozoan)
      0 (Antigens, Protozoan)
    • Publication Date:
      Date Created: 19900401 Date Completed: 19900523 Latest Revision: 20190510
    • Publication Date:
      20240104
    • Accession Number:
      PMC1535222
    • Accession Number:
      10.1111/j.1365-2249.1990.tb06444.x
    • Accession Number:
      2323102