Association of long-term exposure to traffic-related air pollution with blood pressure and hypertension in an adult population-based cohort in Spain (the REGICOR study).

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  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-9924 (Electronic) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Air Pollution/*adverse effects ; Blood Pressure/*drug effects; Air Pollutants/toxicity ; Female ; Humans ; Hypertension/chemically induced ; Male ; Nitrogen Dioxide/toxicity ; Spain
    • Abstract:
      Background: Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure to traffic noise and biased due to inappropriate control for use of BP-lowering medications.
      Objectives: We evaluated the associations of long-term traffic-related air pollution with BP and prevalent hypertension, adjusting for transportation noise and assessing different methodologies to control for BP-lowering medications.
      Methods: We measured systolic (SBP) and diastolic BP (DBP) at baseline (years 2003-2005) in 3,700 participants, 35-83 years of age, from a population-based cohort in Spain. We estimated home outdoor annual average concentrations of nitrogen dioxide (NO2) with a land-use regression model. We used multivariate linear and logistic regression.
      Results: A 10-μg/m3 increase in NO2 levels was associated with 1.34 mmHg (95% CI: 0.14, 2.55) higher SBP in nonmedicated individuals, after adjusting for transportation noise. Results were similar in the entire population after adjusting for medication, as commonly done, but weaker when other methods were used to account for medication use. For example, when 10 mmHg were added to the measured SBP levels of medicated participants, the association was β = 0.78 (95% CI: -0.43, 2.00). NO2 was not associated with hypertension. Associations of NO2 with SBP and DBP were stronger in participants with cardiovascular disease, and the association with SBP was stronger in those exposed to high traffic density and traffic noise levels ≥ 55 dB(A).
      Conclusions: We observed a positive association between long-term exposure to NO2 and SBP, after adjustment for transportation noise, which was sensitive to the methodology used to account for medication.
    • References:
      Circulation. 2012 Feb 14;125(6):767-72. (PMID: 22219348)
      Hypertension. 2013 Mar;61(3):578-84. (PMID: 23357184)
      Occup Environ Med. 2011 Mar;68(3):224-30. (PMID: 20935292)
      J Expo Sci Environ Epidemiol. 2007 Mar;17(2):170-81. (PMID: 16721413)
      Circulation. 2007 Jul 31;116(5):489-96. (PMID: 17638927)
      Environ Health Perspect. 2011 Dec;119(12):1706-11. (PMID: 21827977)
      Circulation. 2010 Jun 1;121(21):2331-78. (PMID: 20458016)
      Eur J Clin Nutr. 2004 Feb;58(2):302-11. (PMID: 14749751)
      Hypertension. 2009 Sep;54(3):659-67. (PMID: 19620518)
      Stat Med. 2005 Oct 15;24(19):2911-35. (PMID: 16152135)
      Eur J Cardiovasc Prev Rehabil. 2007 Oct;14(5):653-9. (PMID: 17925624)
      J Hypertens. 2012 Jun;30(6):1075-86. (PMID: 22473017)
      Gac Sanit. 2005 Sep-Oct;19(5):363-9. (PMID: 16242094)
      Environ Health. 2011 Oct 28;10:92. (PMID: 22034939)
      Epidemiology. 2010 May;21(3):396-404. (PMID: 20335815)
      J Clin Hypertens (Greenwich). 2006 Jun;8(6):444-9. (PMID: 16760685)
      J Air Waste Manag Assoc. 2006 Jun;56(6):709-42. (PMID: 16805397)
      PLoS One. 2010 Feb 08;5(2):e9096. (PMID: 20161713)
      Environ Health Perspect. 2008 Apr;116(4):486-91. (PMID: 18414631)
      Environ Health Perspect. 2012 Jan;120(1):50-5. (PMID: 21885382)
      Stat Med. 2008 Oct 30;27(24):5039-53. (PMID: 18613245)
      Curr Med Res Opin. 2004 Jul;20(7):1137-42. (PMID: 15265258)
      J Occup Environ Med. 2010 Mar;52(3):258-62. (PMID: 20190657)
      Environ Health Perspect. 2013 Feb;121(2):223-30. (PMID: 23384708)
      Hypertension. 2003 Dec;42(6):1206-52. (PMID: 14656957)
      Occup Environ Med. 2012 Jun;69(6):422-7. (PMID: 22383587)
      Environ Health Perspect. 2012 Mar;120(3):418-24. (PMID: 22214647)
      Med Sci Sports Exerc. 2000 Aug;32(8):1431-7. (PMID: 10949009)
      Prog Cardiovasc Dis. 2011 Mar-Apr;53(5):334-43. (PMID: 21414468)
      Occup Environ Med. 2011 Oct;68(10):765-70. (PMID: 21285243)
      Environ Res. 2009 Jul;109(5):582-9. (PMID: 19394925)
      Environ Health Perspect. 2008 Mar;116(3):329-33. (PMID: 18335099)
      Am J Public Health. 2011 Dec;101 Suppl 1:S94-101. (PMID: 22021315)
      Occup Environ Med. 2011 Jan;68(1):64-8. (PMID: 20833756)
      J Cardiovasc Dis Res. 2010 Oct;1(4):196-202. (PMID: 21264184)
      Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):36-44. (PMID: 19029991)
    • Accession Number:
      0 (Air Pollutants)
      S7G510RUBH (Nitrogen Dioxide)
    • Publication Date:
      Date Created: 20140218 Date Completed: 20141125 Latest Revision: 20220311
    • Publication Date:
      20240104
    • Accession Number:
      PMC3984222
    • Accession Number:
      10.1289/ehp.1306497
    • Accession Number:
      24531056