Combined effect of strontium and zoledronate on hydroxyapatite structure and bone cell responses.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
    • Publication Information:
      Publication: <1995-> : Amsterdam : Elsevier Science
      Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980-
    • Subject Terms:
      Diphosphonates/*pharmacology ; Durapatite/*chemistry ; Imidazoles/*pharmacology ; Osteocytes/*drug effects ; Strontium/*pharmacology; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coculture Techniques ; Diphosphonates/chemistry ; Humans ; Imidazoles/chemistry ; Nanoparticles/chemistry ; Osteoblasts/chemistry ; Osteoblasts/drug effects ; Osteocytes/metabolism ; Strontium/chemistry ; Zoledronic Acid
    • Abstract:
      The influence of the simultaneous presence of the two inhibitors of bone degradation, strontium and zoledronate, on the direct synthesis of hydroxyapatite was explored in the range of Sr concentration up to 50 atom% at two different bisphosphonate concentrations (ZOL7 and ZOL14). The results of structural analysis indicated that HA can be obtained as a single crystalline phase up to a Sr concentration in solution of 20 and 10 atom% within the ZOL7 and ZOL14 series respectively. Both Sr substitution and ZOL incorporation affect the length of the coherently scattering crystalline domains and the dimensions of HA nanocrystals. At greater Sr content, XRD full profile fitting data indicate that zoledronate provokes the segregation of Sr in two crystalline apatitic phases, at different strontium content. Co-cultures of osteoblast-like MG63 cells and human osteoclast show that ZOL displays a greater inhibitory influence than Sr on osteoclast proliferation and activity. On the other hand, the results obtained on osteoblast surnatant and on gene expression indicate that Sr exerts a greater promotion on osteoblast proliferation and differentiation. The co-presence of Sr and ZOL has a combined effect on the differentiation markers, so that HA containing about 4 wt% ZOL and 4 Sr atom%, and even more HA containing about 4 wt% ZOL and 8 Sr atom%, result the best compromise for osteoblast promotion and osteoclast inhibition.
      (Copyright © 2014 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bisphosphonates; Co-cultures; Hydroxyapatite; Osteoblast; Osteoclast; Strontium
    • Accession Number:
      0 (Diphosphonates)
      0 (Imidazoles)
      6XC1PAD3KF (Zoledronic Acid)
      91D9GV0Z28 (Durapatite)
      YZS2RPE8LE (Strontium)
    • Publication Date:
      Date Created: 20140416 Date Completed: 20141228 Latest Revision: 20181202
    • Publication Date:
      20240104
    • Accession Number:
      10.1016/j.biomaterials.2014.03.053
    • Accession Number:
      24731709